Monteiro J L G C, Sillmann Y M, Kambakhsh T M, Bei M, Guastaldi F P S
Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.
Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Int J Oral Maxillofac Surg. 2025 Aug;54(8):757-764. doi: 10.1016/j.ijom.2025.01.007. Epub 2025 Jan 30.
The aim of this scoping review was to summarize the results of large animal models investigating the molecular mechanisms of temporomandibular joint degenerative diseases (TMJ-DD). A search of the PubMed/MEDLINE, Embase, and Cochrane Library databases was performed, up to April 2024, using specific terms related to large animals and TMJ-DD. Identified studies had to be published in English. Two reviewers independently selected articles based on the inclusion criteria, with disagreements resolved by a senior author. Compliance with the ARRIVE guidelines was assessed for all studies, evaluating adherence to reporting standards across 21 checklist items. The search yielded 649 non-duplicate articles, of which 616 were excluded after title and abstract screening . The remaining 33 articles and one additional study identified in a hand-search underwent full-text review . Ultimately, seven studies were included, with three focusing on sheep, two on horses, and two on pigs. This review summarizes the biological markers involved in TMJ-DD and discusses their relevance in developing targeted and minimally invasive strategies to prevent the initiation and/or progression of joint disease.
本综述的目的是总结大型动物模型研究颞下颌关节退行性疾病（TMJ-DD）分子机制的结果。截至2024年4月，使用与大型动物和TMJ-DD相关的特定术语，对PubMed/MEDLINE、Embase和Cochrane图书馆数据库进行了检索。纳入的研究必须以英文发表。两名评审员根据纳入标准独立选择文章，如有分歧由资深作者解决。评估了所有研究对ARRIVE指南的遵守情况，评估了21项清单项目对报告标准的遵守情况。检索得到649篇非重复文章，其中616篇在标题和摘要筛选后被排除。其余33篇文章和在手工检索中确定的另一项研究进行了全文审查。最终，纳入了7项研究，其中3项聚焦于绵羊，2项聚焦于马，2项聚焦于猪。本综述总结了TMJ-DD中涉及的生物标志物，并讨论了它们在制定有针对性的微创策略以预防关节疾病的发生和/或进展方面的相关性。
