Peng Shuchang, Li Chenglin, He Yanwen, Xue Lei, Guo Xiaowei
The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Basic Medical Sciences, Hunan Normal University, Changsha, China.
The Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha, China.
Cell Death Discov. 2025 Jan 31;11(1):36. doi: 10.1038/s41420-025-02316-z.
The Hippo pathway represents a highly conserved evolutionary pathway, dysfunction of which has been implicated in various diseases. RNA-binding proteins (RBPs) intricately modulate gene expression through interacting with non-coding RNAs or other proteins. To data, while an array of RBPs have been identified as modulators of the Hippo pathway, there remains a notable absence of a comprehensive review addressing the mechanistic regulations of RBPs in the transduction of Hippo signaling. Herein, this review aims to consolidate recent advances and elucidate the intricate mechanisms underlying RBPs binding to target RNA. It also explores the dynamic interplay between RBPs, non-coding RNAs, TFs, and DNA on chromatin. Additionally, it also outlines future perspectives, including the essential non-canonical functions of RBPs and emerging roles of non-canonical RBPs as transcription factors (TFs) in genes transcription. Overall, this review provides mechanistic insights into the roles of eukaryotic RBP proteins in the regulation of crucial signaling cascades.
河马通路代表了一条高度保守的进化途径，其功能失调与多种疾病有关。RNA结合蛋白（RBPs）通过与非编码RNA或其他蛋白质相互作用来复杂地调节基因表达。到目前为止，虽然一系列RBPs已被确定为河马通路的调节因子，但仍然明显缺乏一篇全面综述来阐述RBPs在河马信号转导中的机制调控。在此，本综述旨在整合最新进展，阐明RBPs与靶RNA结合的复杂机制。它还探讨了RBPs、非编码RNA、转录因子（TFs）和染色质上的DNA之间的动态相互作用。此外，它还概述了未来的研究方向，包括RBPs的重要非经典功能以及非经典RBPs作为转录因子（TFs）在基因转录中的新作用。总的来说，本综述为真核RBP蛋白在关键信号级联调节中的作用提供了机制性见解。
