The conserved IR75 subfamily mediates carboxylic acid detection in insects of public health and agricultural importance.

Insects perceive and respond to carboxylic acids (CAs), amines, and aldehydes primarily via conserved ionotropic receptors (IRs). These receptors form the basis for a second olfactory system distinct from the well-characterized odorant receptors. Neurons expressing IRs are housed in dedicated sensilla and innervate glomeruli, separate from those innervated by odorant receptor neurons. The IR8a co-receptor is highly conserved across insect orders and, together with ionotropic receptor tuning receptors, primarily detects CAs. The conservation of genes and the anatomical separation of neural pathways underscore the importance of these compound classes and CAs, specifically in insect chemical ecology. We provide a summary of carboxylic acid detection in insects, focusing on dipteran and lepidopteran species of significance to public health and agriculture. An overview of insect behavior toward CAs is provided, as well as a comprehensive update on carboxylic acid receptor function in insects. Phylogenetic analysis of publicly available genome databases reveals several species that encode and express homologs of previously deorphanized carboxylic acid receptors, highlighting avenues for future research.