Tochigi Mei, Takamiya Yuko, Ochiai Sawako, Anzawa Kazushi, Tsutsui Kiyohiro, Shimizu Akira
Department of Dermatology, Kanazawa Medical University, Ishikawa, Japan.
Department of Dermatology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
J Dermatol. 2025 Apr;52(4):754-757. doi: 10.1111/1346-8138.17653. Epub 2025 Feb 1.
"Butcher's warts" are skin lesions caused by human papillomavirus type 7 (HPV type 7). Another clinically distinctive lesion, "warts in toe webs" (WTW), localized between the toes, has also been reported but remains poorly understood. We report the case of an 84-year-old man with a refractory, cauliflower-like lesion between his toes which was unresponsive to yokuinin and liquid nitrogen cryotherapy. The patient had no history of meat of fish handling. Biopsy revealed papillary thickening of the stratum corneum and vacuolated cells. Polymerase chain reaction and immunohistochemistry analysis confirmed HPV type 7. Treatment modifications, including maintaining a dry interdigital environment, led to resolution within 2 months. Our review of 19 previously reported WTW cases indicates a distinct clinical profile: all cases involved males from Asia, with a prevalence of fungal coinfection. This case indicates the importance of HPV typing for diagnosis and maintaining a dry interdigital environment to enhance treatment outcomes.
“屠夫疣”是由7型人乳头瘤病毒（HPV - 7）引起的皮肤病变。另一种临床上有明显特征的病变“趾间疣”（WTW），局限于脚趾间，也有相关报道，但人们对其了解仍然有限。我们报告了一例84岁男性病例，其脚趾间有一个难治性的菜花状病变，对尤尼丁和液氮冷冻疗法均无反应。该患者无接触肉类或鱼类的病史。活检显示角质层乳头样增厚和空泡化细胞。聚合酶链反应和免疫组化分析证实为HPV - 7型。包括保持趾间干燥环境在内的治疗调整，使病变在2个月内消退。我们对19例先前报道的趾间疣病例的回顾表明了其独特的临床特征：所有病例均为亚洲男性，且合并真菌感染的发生率较高。该病例表明HPV分型对诊断的重要性，以及保持趾间干燥环境以提高治疗效果的重要性。
