2013 - 2018年智利、圭亚那和巴拉圭流感疫苗预防的疾病：评估疫苗接种价值的标准化方法
Influenza Vaccine-Averted Illness in Chile, Guyana, and Paraguay During 2013-2018: A Standardized Approach to Assess the Value of Vaccination.
作者信息
Jara Jorge H, Loayza Sergio, Nogareda Francisco, Couto Paula, Descalzo Miguel Angel, Chard Anna N, Olivares Barraza María Fernanda, Vergara Mallegas Natalia, Fasce Rodrigo A, Von Horoch Marta, Battaglia Silvia, Penayo Elena, Dominguez Chavely Montserrat, Vazquez Cynthia, Escalada Rainier, Woolford Janice, Michel Fabiana, Chacon Rafael, Fowlkes Ashley, Castro Laura, Velandia-Gonzalez Martha, Rondy Marc, Azziz-Baumgartner Eduardo, Tempia Stefano, Salas Daniel
机构信息
Special Program Comprehensive Immunization, Pan American Health Organization, World Health Organization, Washington, District of Columbia, USA.
Special Program Comprehensive Immunization, Pan American Health Organization, World Health Organization, Guatemala City, Guatemala.
出版信息
J Infect Dis. 2025 Mar 10;231(Supplement_2):S133-S143. doi: 10.1093/infdis/jiaf038.
BACKGROUND
To better establish the value of vaccination against influenza viruses, we estimated vaccine-averted influenza illnesses among young children and older adults in Chile, Guyana, and Paraguay.
METHODS
We gathered country- and target population-specific data on monthly influenza hospitalizations, vaccine coverage, and vaccine effectiveness from surveillance records and immunization registries during 2013-2018. We applied a static compartmental model to estimate differences in the number influenza-associated respiratory disease events (symptomatic nonhospitalized illnesses, medically attended illnesses, hospitalizations) in the presence and absence of influenza vaccination programs.
RESULTS
Between 2013 and 2018, vaccinating 68% of children aged 6-23 months in Chile averted an annual mean of 14 617 nonhospitalized, 9426 medically attended, and 328 hospitalized influenza illnesses; vaccinating 28% of children aged 6-23 months in Paraguay averted 1115 nonhospitalized, 719 medically attended, and 25 hospitalized influenza illnesses. Vaccinating 59% of older adults in Chile averted an annual mean of 83 429 nonhospitalized, 37 079 medically attended, and 1390 hospitalized influenza illnesses; vaccinating 36% of older adults in Paraguay averted an annual mean of 3932 nonhospitalized, 1748 medically attended, and 66 hospitalized influenza illnesses. In Guyana, a hypothetical campaign vaccinating 30% of children aged <5 years could have prevented an annual 1496 nonhospitalized, 971 medically attended, and 10 hospitalized influenza illnesses. Vaccinating 30% of adults aged ≥65 years could have prevented 568 nonhospitalized, 257 medically attended, and 10 hospitalized influenza illnesses.
CONCLUSIONS
Influenza vaccination averted tens of thousands of illnesses and thousands of hospitalizations in Chile and Paraguay; influenza vaccination could have had a proportional benefit in Guyana.
背景
为了更好地确定流感病毒疫苗接种的价值，我们估算了智利、圭亚那和巴拉圭的幼儿及老年人中因接种疫苗而避免的流感病例数。
方法
我们从2013年至2018年的监测记录和免疫登记中收集了特定国家和目标人群的每月流感住院数据、疫苗接种覆盖率和疫苗效力。我们应用了一个静态分区模型来估算在有和没有流感疫苗接种计划的情况下，与流感相关的呼吸道疾病事件（有症状的非住院病例、就医病例、住院病例）数量的差异。
结果
在2013年至2018年期间，智利68%的6至23个月大儿童接种疫苗后，每年平均避免了14617例非住院流感病例、9426例就医流感病例和328例住院流感病例；巴拉圭28%的6至23个月大儿童接种疫苗后，避免了1115例非住院流感病例、719例就医流感病例和25例住院流感病例。智利59%的老年人接种疫苗后，每年平均避免了83429例非住院流感病例、37079例就医流感病例和1390例住院流感病例；巴拉圭36%的老年人接种疫苗后，每年平均避免了3932例非住院流感病例、1748例就医流感病例和66例住院流感病例。在圭亚那，一项假设性的运动为30%的5岁以下儿童接种疫苗，每年可预防1496例非住院流感病例、971例就医流感病例和10例住院流感病例。为30%的65岁及以上成年人接种疫苗，可预防568例非住院流感病例、257例就医流感病例和10例住院流感病例。
结论
流感疫苗接种在智利和巴拉圭避免了数以万计的病例和数千例住院病例；流感疫苗接种在圭亚那可能也有相应的益处。
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