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硅胶凝胶与硅胶凝胶联合577纳米二极管激光治疗术后增生性瘢痕的比较研究

Silicone gel versus combination of silicone gel and a 577-nm diode laser in the treatment of post-surgery hypertrophic scar (comparative study).

作者信息

Mohamed Essam-Elden M, Abd-Elaleem Hazem L, Zahran Samar Ali Abodief

机构信息

Department of Dermatology, Andrology and Venerology, Faculty of Medicine, Al-Azhar University (Assiut), Cairo, Egypt.

Resident doctor in Student Health Care Unit, Al-Azhar University, Asyut, Egypt.

出版信息

Arch Dermatol Res. 2025 Feb 1;317(1):324. doi: 10.1007/s00403-024-03697-4.

Abstract

BACKGROUND

Hypertrophic scars, resulting from alterations in the normal processes of cutaneous wound healing, are characterized by proliferation of dermal tissue with excessive deposition of fibroblast-derived extracellular matrix proteins, especially collagen, over long periods, and by persistent inflammation and fibrosis. The present study aim to compare the efficacy of silicone gel versus combination of a 577-nm pro- yellow laser and silicone gel in the treatment of post-surgery hypertrophic scar.

METHODS

This study is a randomized comparative study In the period from 14 January 2021 up to the end of January 2023. 30 patients with post-surgery hypertrophic scar divided into two groups: A: one half of scar was managed with 577 nm diode laser 3 sessions monthly combined with application of silicone gel at home. A + B: the entire scar was treated with silicone gel within six months who admitted to the Laser unit of the Dermatology and Andrology Department at Al-Azhar University Hospital, Assiut during the study period.

RESULTS

Significant improvement in pigmentation, pliability, height and total Vancouver score. By comparing between silicone gel and combination of silicone gel and a 577 nm diode laser, the combination shows significant improving than silicone gel alone. The scar in the lip and breast area showed a significant higher improvement rate with yellow laser plus silicone gel compared to the other site.

CONCLUSION

Combination of silicone gel and yellow laser has significant effect in making surgical scars less distinct.

摘要

背景

肥厚性瘢痕是由皮肤伤口愈合的正常过程改变引起的,其特征是真皮组织增生,成纤维细胞衍生的细胞外基质蛋白,尤其是胶原蛋白长期过度沉积,以及持续的炎症和纤维化。本研究旨在比较硅胶凝胶与577纳米黄光激光联合硅胶凝胶治疗手术后肥厚性瘢痕的疗效。

方法

本研究是一项随机对照研究,时间从2021年1月14日至2023年1月底。30例手术后肥厚性瘢痕患者分为两组:A组:瘢痕的一半每月用577纳米二极管激光治疗3次,并在家中联合应用硅胶凝胶。A+B组:在研究期间,于阿斯尤特艾资哈尔大学医院皮肤科和男科激光科就诊的患者,其整个瘢痕在6个月内用硅胶凝胶治疗。

结果

色素沉着、柔韧性、高度和温哥华总分均有显著改善。通过比较硅胶凝胶与硅胶凝胶联合577纳米二极管激光,联合治疗组的改善效果明显优于单纯硅胶凝胶组。与其他部位相比,唇部和乳房区域的瘢痕在黄光激光加硅胶凝胶治疗下的改善率显著更高。

结论

硅胶凝胶与黄光激光联合应用对减轻手术瘢痕的明显程度有显著效果。

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