Department of Dermatology and Venerology, West China Hospital of Sichuan University, Chengdu, China.
Department of Abdominal Cancer, West China Hospital of Sichuan University, Chengdu, China.
Int Wound J. 2020 Jun;17(3):765-773. doi: 10.1111/iwj.13337. Epub 2020 Mar 2.
To assess the efficacy of topical silicone gel in the management of scars, we conducted this meta-analysis. The systematic search was performed on PubMed, Web of Science and Embase, and six randomised controlled trials with a total of 375 patients were involved. The outcome data of Vancouver Scar Scale were extracted from the studies and their effect sizes were calculated using Review Manager 5.3. As a result, topical silicone gel significantly reduced pigmentation, height, and pliability scores postoperatively compared with placebos or no treatment (Pigmentation: standard mean difference [SMD] = -0.55 [-0.83 to -0.26], P = .0002; Height: SMD = -0.73 [-1.02 to -0.44], P < .00001; Pliability: SMD = -0.49 [-0.95 to -0.03], P = .04). Topical silicone gel and silicone gel sheet were comparably effective (P > .05). The performance of topical silicone gel and other non-silicone topical treatment was also similar (P > .05). In summary, topical silicone gel was effective in post-operative scar prevention.
为了评估局部硅凝胶在疤痕管理中的疗效，我们进行了这项荟萃分析。系统检索了 PubMed、Web of Science 和 Embase，并纳入了 6 项随机对照试验，共有 375 名患者。从研究中提取温哥华疤痕量表的结局数据，并使用 Review Manager 5.3 计算其效应量。结果显示，与安慰剂或空白对照相比，局部硅凝胶可显著降低术后的色素沉着、高度和柔韧性评分（色素沉着：标准化均数差 [SMD] = -0.55 [-0.83 至 -0.26]，P =.0002；高度：SMD = -0.73 [-1.02 至 -0.44]，P < .00001；柔韧性：SMD = -0.49 [-0.95 至 -0.03]，P =.04）。局部硅凝胶和硅凝胶片的效果相当（P > .05）。局部硅凝胶与其他非硅酮类局部治疗的效果也相似（P > .05）。总之，局部硅凝胶在术后疤痕预防中有效。
