硅酮凝胶治疗瘢痕的疗效：随机对照试验的系统评价和荟萃分析。
Efficacy of topical silicone gel in scar management: A systematic review and meta-analysis of randomised controlled trials.
机构信息
Department of Dermatology and Venerology, West China Hospital of Sichuan University, Chengdu, China.
Department of Abdominal Cancer, West China Hospital of Sichuan University, Chengdu, China.
出版信息
Int Wound J. 2020 Jun;17(3):765-773. doi: 10.1111/iwj.13337. Epub 2020 Mar 2.
Abstract
To assess the efficacy of topical silicone gel in the management of scars, we conducted this meta-analysis. The systematic search was performed on PubMed, Web of Science and Embase, and six randomised controlled trials with a total of 375 patients were involved. The outcome data of Vancouver Scar Scale were extracted from the studies and their effect sizes were calculated using Review Manager 5.3. As a result, topical silicone gel significantly reduced pigmentation, height, and pliability scores postoperatively compared with placebos or no treatment (Pigmentation: standard mean difference [SMD] = -0.55 [-0.83 to -0.26], P = .0002; Height: SMD = -0.73 [-1.02 to -0.44], P < .00001; Pliability: SMD = -0.49 [-0.95 to -0.03], P = .04). Topical silicone gel and silicone gel sheet were comparably effective (P > .05). The performance of topical silicone gel and other non-silicone topical treatment was also similar (P > .05). In summary, topical silicone gel was effective in post-operative scar prevention.
摘要
为了评估局部硅凝胶在疤痕管理中的疗效，我们进行了这项荟萃分析。系统检索了 PubMed、Web of Science 和 Embase，并纳入了 6 项随机对照试验，共有 375 名患者。从研究中提取温哥华疤痕量表的结局数据，并使用 Review Manager 5.3 计算其效应量。结果显示，与安慰剂或空白对照相比，局部硅凝胶可显著降低术后的色素沉着、高度和柔韧性评分（色素沉着：标准化均数差 [SMD] = -0.55 [-0.83 至 -0.26]，P =.0002；高度：SMD = -0.73 [-1.02 至 -0.44]，P < .00001；柔韧性：SMD = -0.49 [-0.95 至 -0.03]，P =.04）。局部硅凝胶和硅凝胶片的效果相当（P > .05）。局部硅凝胶与其他非硅酮类局部治疗的效果也相似（P > .05）。总之，局部硅凝胶在术后疤痕预防中有效。
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