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褪黑素用于治疗发育正常(TD)儿童的失眠:一份技术报告。

Melatonin use in managing insomnia in typically developing (TD) children: A technical report.

作者信息

Owens Judith, Simakajornboon Narong, Kotagal Suresh, Gringras Paul

机构信息

Department of Neurology, Pediatric Sleep Center, Boston Children's Hospital, Boston, MA, USA.

Sleep Center, Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, USA; Department of Pediatric, University of Cincinnati College of Medicine, 3333 Burnet Ave, MLC 7041, Cincinnati, OH, 45229, USA.

出版信息

Sleep Med. 2025 Apr;128:89-94. doi: 10.1016/j.sleep.2025.01.031. Epub 2025 Jan 27.

Abstract

Although melatonin is widely used globally for the management of insomnia in children and adolescents, there are few clinical guidelines available for healthcare practitioners, particularly in typically developing (TD) children. Because existing data are either sparse or inconclusive, a task force comprised of pediatric sleep researchers and clinicians was established by the International Pediatric Sleep Association (IPSA) to first examine the available literature and to develop a set of evidence-based (when possible) and consensus-based recommendations to guide practitioners in decision-making regarding melatonin use in pediatric insomnia. A summary of the evidence pertaining to melatonin's use in pediatric clinical settings, and efficacy and safety in TD children is presented below as a companion to an accompanying list of specific recommendations.

摘要

尽管褪黑素在全球范围内被广泛用于治疗儿童和青少年的失眠,但针对医疗从业者的临床指南却很少,尤其是在发育正常(TD)的儿童中。由于现有数据要么稀少,要么没有定论,国际儿科睡眠协会(IPSA)成立了一个由儿科睡眠研究人员和临床医生组成的特别工作组,首先审查现有文献,并制定一套基于证据(如果可能)和共识的建议,以指导从业者在儿科失眠中使用褪黑素的决策。以下是与褪黑素在儿科临床环境中的使用以及TD儿童的疗效和安全性相关的证据总结,作为随附的具体建议列表的补充。

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