• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

健康儿童中与睡眠相关的褪黑素使用情况。

Sleep-related melatonin use in healthy children.

作者信息

Janjua Irvin, Goldman Ran D

出版信息

Can Fam Physician. 2016 Apr;62(4):315-7.

PMID:27076541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4830653/
Abstract

QUESTION

A mother brought her 12-year-old son into my office because she is concerned that he has difficulty falling asleep almost every night. Her job involves shift work and she uses melatonin herself to help her fall asleep. She asked if her son could take melatonin. What are the recommendations and considerations for using melatonin in otherwise healthy children and adolescents?

ANSWER

Insomnia is reported in up to a quarter of healthy children and in three-quarters of children with neurodevelopmental and psychiatric conditions, resulting in negative consequences. For children with delayed sleep phase syndrome, melatonin can be a useful treatment together with insomnia evaluation and regular follow-up. For children with otherwise undiagnosed insomnia and healthy sleep hygiene, melatonin use should be considered. While melatonin seems to be safe, there is a lack of evidence for its routine use among healthy children.

摘要

问题

一位母亲带着她12岁的儿子来到我的办公室,因为她担心儿子几乎每晚都难以入睡。她的工作需要轮班,她自己服用褪黑素帮助入睡。她问儿子是否可以服用褪黑素。对于健康的儿童和青少年使用褪黑素,有哪些建议和需要考虑的因素?

答案

据报道,多达四分之一的健康儿童以及四分之三患有神经发育和精神疾病的儿童存在失眠问题,这会产生负面影响。对于患有睡眠相位延迟综合征的儿童,褪黑素可作为一种有用的治疗方法,同时要进行失眠评估和定期随访。对于其他未确诊失眠且睡眠卫生良好的儿童,应考虑使用褪黑素。虽然褪黑素似乎是安全的,但缺乏在健康儿童中常规使用的证据。

相似文献

1
Sleep-related melatonin use in healthy children.健康儿童中与睡眠相关的褪黑素使用情况。
Can Fam Physician. 2016 Apr;62(4):315-7.
2
[Melatonin for children with insomnia].[褪黑素用于失眠儿童]
Ugeskr Laeger. 2018 May 7;180(19).
3
[Disturbed sleep in children with ADHD: is there a place for melatonin as a treatment option?].[注意缺陷多动障碍儿童的睡眠障碍:褪黑素作为一种治疗选择是否可行?]
Tijdschr Psychiatr. 2013;55(5):349-57.
4
European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children.欧洲专家关于典型发育儿童睡眠起始失眠管理和褪黑素使用的指导意见。
Eur J Pediatr. 2024 Jul;183(7):2955-2964. doi: 10.1007/s00431-024-05556-w. Epub 2024 Apr 16.
5
Insomnia: the Sleeping Giant of Pediatric Public Health.失眠:儿科公共卫生领域的沉睡巨头。
Curr Psychiatry Rep. 2016 May;18(5):47. doi: 10.1007/s11920-016-0687-0.
6
Melatonin for chronic insomnia in Angelman syndrome: a randomized placebo-controlled trial.褪黑素治疗天使综合征慢性失眠:一项随机安慰剂对照试验
J Child Neurol. 2008 Jun;23(6):649-54. doi: 10.1177/0883073808314153.
7
Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia.多动症和慢性入睡性失眠儿童褪黑素治疗的长期随访
J Pineal Res. 2009 Aug;47(1):1-7. doi: 10.1111/j.1600-079X.2009.00681.x. Epub 2009 May 27.
8
[Insomnia in hospital].[医院中的失眠症]
Ned Tijdschr Geneeskd. 2018;162:D1546.
9
Question 1. Does melatonin improve sleep pattern in children with attention deficit hyperactivity disorder?问题1. 褪黑素能否改善注意力缺陷多动障碍儿童的睡眠模式?
Arch Dis Child. 2009 Apr;94(4):321-2. doi: 10.1136/adc.2008.154435.
10
The use and misuse of exogenous melatonin in the treatment of sleep disorders.外源性褪黑素在治疗睡眠障碍中的应用与误用。
Curr Opin Pulm Med. 2018 Nov;24(6):543-548. doi: 10.1097/MCP.0000000000000522.

引用本文的文献

1
Allergic Conditions and Their Impact on Pediatric Sleep: A Narrative Review.过敏病症及其对儿童睡眠的影响:一篇叙述性综述
J Pharm Bioallied Sci. 2024 Dec;16(Suppl 5):S4205-S4209. doi: 10.4103/jpbs.jpbs_1264_24. Epub 2025 Jan 30.
2
Parental Experiences of Melatonin Administration to Manage Sleep Disturbances in Autistic Children and Adolescent in the UK.英国父母给自闭症儿童和青少年服用褪黑素治疗睡眠障碍的经历。
Healthcare (Basel). 2023 Jun 16;11(12):1780. doi: 10.3390/healthcare11121780.
3
Administration in Efficacy of Melatonin Reducing Headaches in Children With Migraines and Sleep Disorders: A Randomized Clinical Trial Study.褪黑素对偏头痛和睡眠障碍儿童头痛减轻效果的给药研究:一项随机临床试验研究
Iran J Child Neurol. 2022 Fall;16(4):55-64. doi: 10.22037/ijcn.v17i2.37918. Epub 2022 Oct 23.
4
Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials.褪黑素治疗神经发育障碍儿童睡眠障碍的系统评价和随机临床试验的荟萃分析及序贯分析方案。
BMJ Open. 2022 Nov 29;12(11):e065520. doi: 10.1136/bmjopen-2022-065520.
5
Management of sleep disorders among children and adolescents with neurodevelopmental disorders: A practical guide for clinicians.神经发育障碍儿童和青少年睡眠障碍的管理:临床医生实用指南。
World J Clin Pediatr. 2022 Mar 15;11(3):239-252. doi: 10.5409/wjcp.v11.i3.239. eCollection 2022 May 9.
6
Hyperphosphorylation of Tau Due to the Interference of Protein Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in Melatonin Receptor Knockout Mice.褪黑素受体敲除小鼠中 miR-125b-5p 通过蛋白磷酸酶甲基转移酶-1 过表达对 Tau 的过度磷酸化作用。
Int J Mol Sci. 2021 Oct 31;22(21):11850. doi: 10.3390/ijms222111850.
7
Efficacy and safety of supplemental melatonin for delayed sleep-wake phase disorder in children: an overview.补充褪黑素治疗儿童睡眠-觉醒时相延迟障碍的疗效与安全性:综述
Sleep Med X. 2020 Aug 19;2:100022. doi: 10.1016/j.sleepx.2020.100022. eCollection 2020 Dec.
8
Melatonin Use in Pediatrics: Evaluating the Discrepancy in Evidence Based on Country and Regulations Regarding Production.褪黑素在儿科中的应用:基于国家和生产法规评估证据差异。
J Pediatr Pharmacol Ther. 2021;26(1):4-20. doi: 10.5863/1551-6776-26.1.4. Epub 2021 Jan 4.
9
Trends in Nutrient- and Non-Nutrient-Containing Dietary Supplement Use among US Children from 1999 to 2016.1999 年至 2016 年美国儿童营养素和非营养素膳食补充剂使用趋势。
J Pediatr. 2021 Apr;231:131-140.e2. doi: 10.1016/j.jpeds.2020.12.021. Epub 2020 Dec 17.
10
Prophylaxis with melatonin for primary stabbing headache in pediatrics: a case report.褪黑素预防小儿原发性刺痛性头痛:一例报告
Colomb Med (Cali). 2018 Sep 30;49(3):244-248. doi: 10.25100/cm.v49i2.3857.

本文引用的文献

1
Melatonin for the management of sleep disorders in children and adolescents.褪黑素用于治疗儿童和青少年的睡眠障碍。
Paediatr Child Health. 2012 Jun;17(6):331-6.
2
Pediatric sleep pharmacology.儿科睡眠药理学。
Child Adolesc Psychiatr Clin N Am. 2012 Oct;21(4):861-83. doi: 10.1016/j.chc.2012.08.001.
3
Pharmacologic treatment of pediatric insomnia.儿童失眠的药物治疗。
Child Adolesc Psychiatr Clin N Am. 2009 Oct;18(4):1001-16. doi: 10.1016/j.chc.2009.04.009.
4
Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia.多动症和慢性入睡性失眠儿童褪黑素治疗的长期随访
J Pineal Res. 2009 Aug;47(1):1-7. doi: 10.1111/j.1600-079X.2009.00681.x. Epub 2009 May 27.
5
Pediatric sleep pharmacology.儿科睡眠药理学
Semin Pediatr Neurol. 2008 Jun;15(2):79-90. doi: 10.1016/j.spen.2008.03.004.
6
Melatonin for insomnia in children with autism spectrum disorders.褪黑素治疗自闭症谱系障碍儿童的失眠症。
J Child Neurol. 2008 May;23(5):482-5. doi: 10.1177/0883073807309783. Epub 2008 Jan 8.
7
Sleep duration from ages 1 to 10 years: variability and stability in comparison with growth.1至10岁儿童的睡眠时间:与生长发育相比的变异性和稳定性
Pediatrics. 2007 Oct;120(4):e769-76. doi: 10.1542/peds.2006-3300.
8
Pharmacologic management of insomnia in children and adolescents: consensus statement.儿童和青少年失眠的药物治疗:共识声明
Pediatrics. 2006 Jun;117(6):e1223-32. doi: 10.1542/peds.2005-1693.
9
Excessive sleepiness in adolescents and young adults: causes, consequences, and treatment strategies.青少年和青年的过度嗜睡:原因、后果及治疗策略。
Pediatrics. 2005 Jun;115(6):1774-86. doi: 10.1542/peds.2005-0772.
10
Developing circadian rhythmicity in infants.婴儿昼夜节律的发展。
Pediatrics. 2003 Aug;112(2):373-81. doi: 10.1542/peds.112.2.373.