Nedeljković M, Matović V, Soldatović D
J Appl Toxicol. 1985 Feb;5(1):11-3. doi: 10.1002/jat.2550050103.
The effect of different concentrations of fluoride (as sodium fluoride) on the enzymes lactate dehydrogenase (LDH, EC 1.1.1.27) and creatine kinase (CK, EC 2.7.3.2) in rabbit plasma was investigated in vivo and in vitro. Rabbits were dosed orally, for 30 days, with fluoride at 2, 10 or 20 mg per kg body weight as sodium fluoride. LDH and CK levels were determined at 10-day intervals during the treatment. Fluoride, depending on the applied dose, inhibited, had no effect or stimulated the investigated enzymes in vivo. On the other hand, fluoride had no effect on the activity of LDH and CK in vitro.
研究了不同浓度的氟化物（以氟化钠形式）对家兔血浆中乳酸脱氢酶（LDH，EC 1.1.1.27）和肌酸激酶（CK，EC 2.7.3.2）的体内和体外作用。家兔经口给予氟化钠，剂量为每千克体重2、10或20毫克，持续30天。在治疗期间每隔10天测定LDH和CK水平。根据给药剂量，氟化物在体内对所研究的酶有抑制、无影响或刺激作用。另一方面，氟化物在体外对LDH和CK的活性无影响。
