实验性兔胰岛素诱导低血糖时的血浆酶变化
Plasma enzymic changes in insulin-induced hypoglycemia in experimental rabbits.
作者信息
Jiang Z L, Harada T, Kohzuki M, Kamimoto M, Sato T
机构信息
Section of Internal Medicine and Disability Prevention, Tohoku University Graduate School, Sendai.
出版信息
Tohoku J Exp Med. 1996 Jul;179(3):219-22. doi: 10.1620/tjem.179.219.
In order to elucidate the effects of hypoglycemia on cardiac and skeletal muscle, plasma activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK) were assessed in rabbits with hypoglycemia induced by i.v. injection of insulin. After hypoglycemia lasting for more than 30 min, the plasma levels of ALT, AST and LDH rose significantly in 4 out of 5 rabbits reaching a peak at 24 hr. The plasma activity of CK rose remarkably and reached a peak at 6 hr after insulin injection in all rabbits. These results suggest prolonged hypoglycemia may cause myocardial and/or skeletal muscle damage, which can be ascertained by measuring plasma activities of the related enzymes.
为了阐明低血糖对心脏和骨骼肌的影响，通过静脉注射胰岛素诱导家兔发生低血糖，然后评估其血浆丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）和肌酸激酶（CK）的活性。在低血糖持续超过30分钟后，5只家兔中有4只的血浆ALT、AST和LDH水平显著升高，在24小时达到峰值。所有家兔的血浆CK活性在注射胰岛素后6小时显著升高并达到峰值。这些结果表明，长时间低血糖可能会导致心肌和/或骨骼肌损伤，这可以通过测量相关酶的血浆活性来确定。
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