El-Tahan Hatem M, Lim Chun Ik, Alhimaidi Ahmad R, Ammari Aiman A, Cho Sungbo, Kim In Ho, El-Tahan Hossam M
Animal Production Research Institute, Ministry of Agriculture, Giza, 12619, Egypt; Department of Animal Science, Jeonbuk National University, Jeonju, 54896, South Korea.
Department of Animal Science, Jeonbuk National University, Jeonju, 54896, South Korea; Poultry Research Institute, National Institute of Animal Science, RDA, Pyeongchang, 25342, South Korea.
Domest Anim Endocrinol. 2025 Apr;91:106915. doi: 10.1016/j.domaniend.2025.106915. Epub 2025 Jan 14.
This study investigated the effects of fish oil (FO) supplementation on the hypothalamus heat resistance gene expressions and fatty acid composition of chicks under acute high-temperature stress, for treating Cholestasis. A total of 48 chicks (Ross 308) at age of 14 days were acclimatized to corn oil or FO (n = 24 for each) by oral gavaging for 10 days, and then subjected to heat stress (35 ± 1 °C, HT) for 3 h or maintained at the normal temperature (26 ± 1 °C, NT) as grouped as NT and FO-NT control and HT and FO-HT (n = 12 for each).. The results showed that FO supplementation had no significant (P > 0.05) effect on feed intake or body weight. The FO-HT group exhibited (P<0.05) a lower rectal temperature, and plasma interleukin-6 (IL-6), triglyceride and corticosterone levels, in accompany with lower expressions of hypothalamic adenine nucleotide translocators (ANT) and uncoupling protein (UCP) but increased (P<0.05) plasma superoxide dismutase activity and hypothalamic neuropeptide-Y (NPY) and heat shock protein-70 (HSP-70) expressions.. Additionally, the FO-HT group (P < 0.05) demonstrated a higher unsaturated fatty acid/saturated fatty acid (UFA/SFA) ratio in the breast muscle. These findings suggest that FO supplementation can enhance the heat resistance of broiler chicks under acute heat stress and alter the fatty acid composition of their breast muscle. However, further studies are needed to determine whether desirable fatty acids can cross the blood-brain barrier and their implications for human health.
本研究调查了补充鱼油（FO）对急性高温应激下雏鸡下丘脑耐热基因表达和脂肪酸组成的影响，以治疗胆汁淤积症。选取48只14日龄的罗斯308雏鸡，通过口服灌胃10天使其适应玉米油或鱼油（每组24只），然后分为常温组（26±1℃，NT）和鱼油常温对照组（FO-NT）、高温组（35±1℃，HT）和鱼油高温组（FO-HT）（每组12只），高温组进行3小时热应激，常温组保持在正常温度。结果表明，补充鱼油对采食量或体重无显著影响（P>0.05）。鱼油高温组的直肠温度、血浆白细胞介素-6（IL-6）、甘油三酯和皮质酮水平较低（P<0.05），同时下丘脑腺嘌呤核苷酸转位酶（ANT）和解偶联蛋白（UCP）的表达较低，但血浆超氧化物歧化酶活性以及下丘脑神经肽Y（NPY）和热休克蛋白70（HSP-70）的表达增加（P<0.05）。此外，鱼油高温组胸肌中不饱和脂肪酸/饱和脂肪酸（UFA/SFA）比值较高（P<0.05）。这些结果表明，补充鱼油可以增强肉仔鸡在急性热应激下的耐热性，并改变其胸肌的脂肪酸组成。然而，需要进一步研究以确定有益脂肪酸是否能够穿过血脑屏障及其对人类健康的影响。
