Spicer Julie, Malaspina Dolores, Blank Stephanie V, Goosens Ki A
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Center for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Center for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Psychiatry Res. 2025 Mar;345:116239. doi: 10.1016/j.psychres.2024.116239. Epub 2024 Oct 28.
The average current life expectancy entails that women will spend over one-third of their lives in menopause. Follicle-stimulating hormone (FSH) levels in women begin to increase roughly six years before the final menstrual period, reaching a menopausal plateau that is nearly 14 times the level of FSH observed in men, a profound sex-specific difference. A promising new body of work examines whether these age-associated increases in FSH contribute to multiple menopause-related conditions, including psychiatric morbidities. This paper highlights research advances showing the potential role of FSH and its underlying mechanisms in mental health conditions for women in menopause and makes the call for more research.
目前的平均预期寿命表明，女性一生中超过三分之一的时间将处于更年期。女性促卵泡生成素（FSH）水平在最后一次月经前约六年开始上升，达到绝经后的稳定水平，这一水平几乎是男性FSH水平的14倍，这是一个显著的性别差异。一项有前景的新研究探讨了与年龄相关的FSH升高是否会导致多种与更年期相关的疾病，包括精神疾病。本文重点介绍了研究进展，展示了FSH及其潜在机制在更年期女性心理健康状况中的潜在作用，并呼吁开展更多研究。
