Wolfson Rachel L
Department of Cell Biology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA; Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Curr Opin Neurobiol. 2025 Feb;90:102973. doi: 10.1016/j.conb.2025.102973. Epub 2025 Jan 31.
Sensing our internal environment, or interoception, is essential under physiologic circumstances, such as controlling food intake, and under pathophysiologic circumstances, often triggering abdominal pain. The sensory neurons that innervate the gastrointestinal (GI) tract to mediate interoception originate in two separate parts of the peripheral nervous system: the spinal sensory neurons, whose cell bodies reside in the dorsal root ganglia (DRG), and the vagal sensory neurons, whose cell bodies reside in the nodose ganglia. While the vagal sensory neurons have been extensively studied for their roles in interoception, the roles of the DRG sensory neurons in internal gut sensing are only beginning to be uncovered. Here, we review the recent advances in understanding the diverse properties and functions of gut-innervating DRG sensory neurons and highlight the many unknowns with regards to this understudied population in regulating interoception.
感知我们的内部环境，即内感受，在生理情况下（如控制食物摄入）以及病理生理情况下（常引发腹痛）都至关重要。支配胃肠道以介导内感受的感觉神经元起源于外周神经系统的两个不同部分：脊髓感觉神经元，其细胞体位于背根神经节（DRG）；迷走感觉神经元，其细胞体位于结状神经节。虽然迷走感觉神经元在介导内感受中的作用已得到广泛研究，但DRG感觉神经元在肠道内部感知中的作用才刚刚开始被揭示。在此，我们回顾了在理解支配肠道的DRG感觉神经元的多样特性和功能方面的最新进展，并强调了在调节内感受方面，这一研究不足的群体仍存在许多未知之处。
