Amaladoss A S, Burton G J
J Dev Physiol. 1985 Apr;7(2):113-8.
Previously published reports have claimed that human placental villi are capable of adapting to hypoxia by thinning of the placental barrier which normally separates the fetal from the maternal circulation. In order to examine this effect further, terminal villi from three normal mature placentas were cultured for periods of 1, 6 and 12 h at different oxygen tensions. Diffusion distance and capillary volume fraction were measured on 1 micron plastic sections on a blind basis, but no statistically significant differences were observed between the cultured sample groups and control material. It is concluded that placental villi show no adaptation to acute hypoxia when maintained in organ culture in vitro. It is possible, however, that they undergo changes in vivo, secondary to vasodilatation of the umbilical arteries and placental arterioles.
先前发表的报告称，人胎盘绒毛能够通过胎盘屏障变薄来适应缺氧，胎盘屏障通常将胎儿循环与母体循环分隔开。为了进一步研究这种效应，取自三个正常成熟胎盘的终末绒毛在不同氧张力下培养1、6和12小时。在盲态下对1微米塑料切片测量扩散距离和毛细血管容积分数，但培养样本组与对照材料之间未观察到统计学上的显著差异。得出的结论是，胎盘绒毛在体外器官培养中对急性缺氧无适应性表现。然而，它们有可能在体内发生变化，继发于脐动脉和胎盘小动脉的血管舒张。
