Hejazian Seyyed Sina, Vemuri Ajith, Vafaei Sadr Alireza, Shahjouei Shima, Bahrami Sasan, Abedi Vida, Zand Ramin
Department of Neurology, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA.
Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, 17033, USA.
J Stroke Cerebrovasc Dis. 2025 Apr;34(4):108246. doi: 10.1016/j.jstrokecerebrovasdis.2025.108246. Epub 2025 Jan 30.
It is widely recognized that a considerable number of COVID-19 survivors continue to experience post-COVID conditions (PCCs). Given that stroke survivors face a heightened risk of PCCs compared to the general population, our objective was to assess the impact of PCCs on the health-related quality of life (HRQL) among stroke survivors in the United States.
We used the Behavioral Risk Factor Surveillance System data 2022. Respondents with a history of COVID-19 infection and stroke were selected and classified based on whether they experienced PCCs. Finally, the HRQL-related items, including self-reported general health (SRGH), the number of days with compromised mental and physical health, and the daily efficiency, were compared between the two groups.
Overall, 3988 respondents (42.8 % aged above 64 years old, 45.8 % men) were enrolled. Compared to stroke survivors without PCCs, those with PCCs had significantly worse SRGH and a higher number of days with compromised mental and physical health. However, although multivariate regression analysis supported the adverse impact of PCCs on the SRGH of stroke survivors, the results were not statistically significant (aOR = 1.32,CI95 %:[0.98-1.78],p = 0.070). Fatigue and dyspnea emerged as the most significantly associated symptoms with impaired SRGH. Additionally, lower education and annual household income level, smoking, lack of physical activity, and comorbidities including diabetes, heart, and pulmonary disease were associated with a higher prevalence of unfavorable SRGH among stroke survivors with PCCs.
Our study highlights that PCCs might be associated with worse SRGH. Lower education, income, and physical activity, smoking, and comorbidities were associated with a higher rate of unfavorable SRGH among stroke survivors with PCCs.
人们普遍认识到，相当数量的新冠病毒感染康复者仍持续经历新冠后状况（PCCs）。鉴于与普通人群相比，中风幸存者面临更高的PCCs风险，我们的目标是评估PCCs对美国中风幸存者健康相关生活质量（HRQL）的影响。
我们使用了2022年行为风险因素监测系统数据。选取有新冠病毒感染和中风病史的受访者，并根据他们是否经历PCCs进行分类。最后，比较两组之间与HRQL相关的项目，包括自我报告的总体健康状况（SRGH）、身心健康受损的天数以及日常效率。
总体而言，共纳入3988名受访者（42.8%年龄在64岁以上，45.8%为男性）。与没有PCCs的中风幸存者相比，有PCCs的患者SRGH明显更差，身心健康受损的天数更多。然而，尽管多变量回归分析支持PCCs对中风幸存者SRGH有不利影响，但结果无统计学意义（调整后比值比[aOR]=1.32，95%置信区间[CI]：[0.98 - 1.78]，p = 0.070）。疲劳和呼吸困难是与SRGH受损最显著相关的症状。此外，较低的教育程度和家庭年收入水平、吸烟、缺乏体育活动以及包括糖尿病、心脏病和肺病在内的合并症与有PCCs的中风幸存者中不良SRGH的较高患病率相关。
我们的研究强调，PCCs可能与更差的SRGH相关。较低的教育程度、收入、体育活动、吸烟以及合并症与有PCCs的中风幸存者中不良SRGH的较高发生率相关。
