McGillis J P, Hall N R, Vahouny G V, Goldstein A L
J Immunol. 1985 Jun;134(6):3952-5.
In these studies it was found that i.p. injection of thymosin fraction 5 (TF5) caused a dose-dependent increase in serum corticosterone in male Swiss Webster mice and in male Wistar rats. The maximum responses were seen at 1 and 2 hr, respectively. There was no effect on serum corticosterone in mice when Thymosin alpha 1 (a 28 amino acid peptide isolated from TF5) was injected i.p. at doses up to 100 micrograms. The steroidogenic effects of TF5 were seen only when the basal levels of serum corticosterone were low (less than 80 ng/ml). In studies in which the baseline levels in the animal colony were elevated (greater than 80 ng/ml), there were no steroidogenic effects, or they were minimal. These results suggest that some component of TF5 may influence pituitary adrenal function.
在这些研究中发现，腹腔注射胸腺素组分5（TF5）可使雄性瑞士韦伯斯特小鼠和雄性Wistar大鼠的血清皮质酮呈剂量依赖性增加。最大反应分别在1小时和2小时出现。当腹腔注射高达100微克剂量的胸腺素α1（从TF5中分离出的一种28个氨基酸的肽）时，对小鼠血清皮质酮没有影响。仅当血清皮质酮的基础水平较低（低于80纳克/毫升）时，才会出现TF5的促肾上腺皮质激素生成作用。在动物群体基线水平升高（大于80纳克/毫升）的研究中，没有促肾上腺皮质激素生成作用，或者作用极小。这些结果表明，TF5的某些成分可能会影响垂体-肾上腺功能。
