Kumar Rajeev
Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin for Plant Sciences (IJPB), 78000, Versailles, France.
Trends Biochem Sci. 2025 Apr;50(4):287-289. doi: 10.1016/j.tibs.2025.01.002.
Homologous recombination (HR) is critical for maintaining genome stability, relying on RAD51 recombinase to catalyze homology-dependent accurate DNA repair. While various cellular modulators control HR, Carver, Yu, et al. reveal a unique molecular mechanism used by FIDGETIN-LIKE-1 (FIGNL1) that dissociates RAD51 from DNA through RAD51 N terminus and FIGNL1 hexamer assembly.
同源重组（HR）对于维持基因组稳定性至关重要，它依赖于RAD51重组酶来催化同源性依赖的精确DNA修复。虽然各种细胞调节剂控制着HR，但卡弗、于等人揭示了FIDGETIN-LIKE-1（FIGNL1）所采用的一种独特分子机制，该机制通过RAD51 N端和FIGNL1六聚体组装使RAD51与DNA解离。
