Yang Yan, Liu Shenghong, Gao Wenwen, Wang Lei, Liu Na, Zhang Shiying, Yang Lianjing, Cheng Lingyun
Kangming Eye Hospital, Taiyuan, China.
Department of Ophthalmology, Jacob's Retina Center at Shiley Eye Institute, University of California San Diego, San Diego, La Jolla, CA, USA.
Sci Rep. 2025 Feb 1;15(1):3996. doi: 10.1038/s41598-024-81363-5.
Defocus incorporated multiple segment (DIMS) lenses and repeated low-level red-light (RLRL) are used to retard myopia progression. However, it is currently unknown if there is a synergistic effect of the two interventions. In the current study, 190 school-aged children with myopia (380 eyes) were studied for the change in axial length (AL) over nearly one year of follow-up. Of 380 eyes, 170 eyes wore DIMS lenses, 80 eyes had RLRL therapy, and 130 eyes had both interventions (DIMS_RLRL) for myopia control. AL changes were calculated at each follow-up visit by subtracting the baseline measurements and normalized to yearly changes in mm. AL changes as a primary outcome were analyzed in a generalized linear mixed model to compare effect sizes of myopia control among three interventions while adjusting for age, sex, baseline axial length, and follow-up length. Participants had a mean age of 9.84 ± 2.63 years old, mean AL of 24.49 ± 1.20 mm, mean SER of -2.90 ± 2.08 diopters, and mean follow-up time of 301 ± 91 days. By the end of the study, the adjusted mean yearly axial change with combination therapy was - 0.13 mm, -0.04 mm for the eyes with RLRL alone, and 0.16 mm for the eyes with DIMS lenses alone (p < 0.0001). Combination therapy of DIMS and RLRL has significantly greater effect size in controlling myopia progression than either RLRL alone (p = 0.0009) or DIMS alone (p < 0.0001).
离焦多区域（DIMS）镜片和重复低强度红光（RLRL）被用于延缓近视进展。然而，目前尚不清楚这两种干预措施是否具有协同效应。在本研究中，对190名近视学龄儿童（380只眼）进行了近一年随访，观察眼轴长度（AL）的变化。在380只眼中，170只眼佩戴DIMS镜片，80只眼接受RLRL治疗，130只眼同时接受两种干预措施（DIMS_RLRL）以控制近视。每次随访时，通过减去基线测量值计算AL变化，并将其标准化为以毫米为单位的年变化。在广义线性混合模型中分析AL变化这一主要结果，以比较三种干预措施在控制近视方面的效应大小，同时对年龄、性别、基线眼轴长度和随访时长进行校正。参与者的平均年龄为9.84±2.63岁，平均AL为24.49±1.20毫米，平均等效球镜度为-2.90±2.08屈光度，平均随访时间为301±91天。研究结束时，联合治疗组调整后的平均年眼轴变化为-0.13毫米，单纯RLRL治疗组为-0.04毫米，单纯DIMS镜片组为0.16毫米（p<0.0001）。DIMS与RLRL联合治疗在控制近视进展方面的效应大小显著大于单纯RLRL治疗（p=0.0009）或单纯DIMS治疗（p<0.0001）。
