Internationale Innovative Ophthalmochirurgie, Breyer Kaymak Klabe Augenchirurgie, Düsseldorf, Germany.
Institute of Experimental Ophthalmology, Saarland University, Homburg, Germany.
BMC Ophthalmol. 2024 Sep 12;24(1):403. doi: 10.1186/s12886-024-03666-5.
This retrospective analysis evaluates the treatment success of "Defocus Incorporated Multiple Segments" (DIMS) spectacle lenses in a real-life clinical setting in Germany.
Axial length (AL) and objective refraction of 166 eyes treated with DIMS at baseline and 12-month follow-up were analyzed. Annual AL growth rate within the range of physiological growth rate was considered a successful treatment. Myopia progression of ≥ -0.5 D/yr accounted as treatment success. Differences in percentages of treatment success of subgroups depending on baseline AL and age against treatment success of the total population were investigated.
Considering all eyes, treatment success regarding AL growth and myopia progression was achieved in 46% and 65%, respectively. Male eyes with moderate AL showed treatment success in a higher proportion (73%, p < 0.01; 89%, p < 0.01); eyes with high AL showed treatment success in a lower proportion (25%, p < 0.01; 51%, n.s.). Female eyes showed the same trend but without statistical significance (moderate AL: 49%; 68%; high AL: 40%; 62%). Younger children showed treatment success in a lower proportion (male: 11%, p < 0.01; 38%, p < 0.05; female: 25%, p < 0.01; 42%, p < 0.01). Older children showed treatment success in a higher proportion (male: 60%, p < 0.05; 78% p < 0.05; female: 53%, n.s.; 77% p < 0.05).
Eyes with moderate baseline AL and of older children showed treatment success after 12 months of DIMS treatment. Eyes with a high baseline AL and of younger children showed treatment success in a smaller proportion, therefore combination treatment should be considered. In future studies, males and females should be assessed separately.
本回顾性分析评估了“离焦多焦点”（DIMS）眼镜在德国真实临床环境中的治疗效果。
对 166 只接受 DIMS 治疗的眼睛的眼轴（AL）和客观屈光度进行了分析，包括基线和 12 个月随访。将生理生长范围内的年 AL 增长率视为成功治疗。近视进展≥-0.5 D/yr 被视为治疗成功。根据基线 AL 和年龄，对亚组的治疗成功率与总人群的治疗成功率进行了比较。
考虑到所有眼睛，在 AL 增长和近视进展方面，分别有 46%和 65%的眼睛达到了治疗成功。中 AL 的男性眼睛的治疗成功率更高（73%，p<0.01；89%，p<0.01）；高 AL 的眼睛的治疗成功率较低（25%，p<0.01；51%，无统计学意义）。女性眼睛也呈现出同样的趋势，但无统计学意义（中 AL：49%；68%；高 AL：40%；62%）。年龄较小的儿童治疗成功率较低（男性：11%，p<0.01；38%，p<0.05；女性：25%，p<0.01；42%，p<0.01）。年龄较大的儿童治疗成功率较高（男性：60%，p<0.05；78%，p<0.05；女性：53%，无统计学意义；77%，p<0.05）。
在接受 DIMS 治疗 12 个月后，中基线 AL 的眼睛和年龄较大的儿童显示出治疗成功。高基线 AL 的眼睛和年龄较小的儿童的治疗成功率较低，因此应考虑联合治疗。在未来的研究中，应分别评估男性和女性。
