Gandomi-Mohammadabadi Milad, Gandomi-Mohammadabadi Alireza, Nasimi Maryam, Etesami Ifa, Mahmoudi Hamidreza, Aryanian Zeinab, Hatami Parvaneh
Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, 1199663911, Tehran, Iran.
Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Arch Dermatol Res. 2025 Feb 1;317(1):337. doi: 10.1007/s00403-025-03835-6.
BACKGROUND & OBJECTIVE: Cutaneous vasculitis has different clinical manifestations. It may be idiopathic or associated with infections, medications, etc.Skin is involved in both small vessel vasculitis (SVV) and medium vascular vasculitis.We aimed to evaluate clinical signs, laboratory and pathological changes of cutaneous vasculitis among Iranian people.
MATERIAL & METHODS: This study was a descriptive study performed on 74 patients with cutaneous vasculitis from March 2011 to February 2019. Information includes histopathological data, as well as clinical variables including the age of onset, sex, area of involvement, type of lesion, symptoms, and diagnosis. Pathological and laboratory changes were collected and recorded as well.
Of the 74 patients studied, hypersensitivity vasculitis 52(70%) was the most common form.Most of the patients had lower extremities involvement. The most common clinical features and symptoms were petechiae or purpura and itching. Fever, limb edema, and arthralgia were the most common symptoms, occurring in 26%, 20%, and 18% of patients, respectively. Among patients, 18 (24%) had taken medication before the lesions, 10 (13%) had vasculitis due to infection, and 44 (59%) were diagnosed as idiopathic form. The most common treatment was prednisolone in 69 patients (93%) with a mean dose of 15.6 ± 35 mg.
The study would be useful in understanding the various specific and non specific features of cutaneous vasculitis, helping the clinician to manage the condition.
皮肤血管炎有不同的临床表现。它可能是特发性的，也可能与感染、药物等有关。皮肤在小血管血管炎（SVV）和中血管血管炎中均会受累。我们旨在评估伊朗人群中皮肤血管炎的临床体征、实验室及病理变化。
本研究为描述性研究，于2011年3月至2019年2月对74例皮肤血管炎患者进行。信息包括组织病理学数据，以及临床变量，如发病年龄、性别、受累部位、病变类型、症状和诊断。同时收集并记录病理和实验室变化。
在研究的74例患者中，过敏性血管炎52例（70%）最为常见。大多数患者下肢受累。最常见的临床特征和症状是瘀点或紫癜以及瘙痒。发热、肢体水肿和关节痛是最常见的症状，分别发生在26%、20%和18%的患者中。患者中，18例（24%）在病变出现前服用过药物，10例（13%）因感染发生血管炎，44例（59%）被诊断为特发性类型。最常用的治疗药物是泼尼松龙，69例患者（93%）使用，平均剂量为15.6±35mg。
该研究有助于了解皮肤血管炎的各种特异性和非特异性特征，帮助临床医生处理该疾病。
