Shah Siddharth, Nag Aiswarya, Lucke-Wold Brandon
Lillian S Wells Department of Neurosurgery, University of Florida, Gainesville, USA.
Clin Transl Oncol. 2025 Feb 1. doi: 10.1007/s12094-025-03849-6.
Glioblastoma (GBM) is a rare and aggressive primary central nervous system tumor with high morbidity and mortality. Standard treatments include surgery, radiotherapy (RT), and temozolomide (TMZ) chemotherapy, but these options are often insufficient and cause severe side effects. Tumor Treating Fields (TTFields) have emerged as a fourth treatment, offering improved survival, better prognosis, and minimal side effects, significantly enhancing the quality of life for GBM patients. For newly diagnosed cases, TTFields combined with TMZ is the recommended standard of care for eligible patients. Current GBM therapy focuses on extending survival while reducing harm. Ongoing research seeks to explore TTFields in innovative radiological-based therapeutic paradigms.
胶质母细胞瘤（GBM）是一种罕见且侵袭性强的原发性中枢神经系统肿瘤，发病率和死亡率都很高。标准治疗方法包括手术、放射治疗（RT）和替莫唑胺（TMZ）化疗，但这些方法往往并不充分，还会引起严重的副作用。肿瘤治疗电场（TTFields）已成为第四种治疗方法，可提高生存率、改善预后且副作用极小，显著提高了GBM患者的生活质量。对于新诊断的病例，TTFields联合TMZ是符合条件患者的推荐标准治疗方案。目前GBM治疗的重点是在减少伤害的同时延长生存期。正在进行的研究旨在探索基于创新放射学的治疗模式中的TTFields。
