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强化生活方式改变对阿尔茨海默病所致轻度认知障碍或早期痴呆进展的影响：严谨性的必要性。

Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: the need for rigor.

作者信息

Grill Joshua D, Gillen Daniel

机构信息

Institute for Memory Impairments and Neurological Disorders, University of California Irvine, 3204 Biological Sciences III, Irvine, CA, 92697, USA.

Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.

出版信息

Alzheimers Res Ther. 2025 Feb 1;17(1):32. doi: 10.1186/s13195-024-01621-6.

DOI:10.1186/s13195-024-01621-6
PMID:39893378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11786341/
Abstract

We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials. We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve rigor in this example, particularly in design, data analysis, and publication of results for this and other lifestyle intervention studies.

摘要

我们考量了奥尼什及其同事最近发表的文章以及介入性临床试验应有的严谨性。我们认为生活方式干预试验应追求与药物试验相同的严谨性，并在这个例子中突出了提高严谨性的机会，特别是在设计、数据分析以及本研究和其他生活方式干预研究的结果发表方面。

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Alzheimers Res Ther. 2025 Feb 1;17(1):32. doi: 10.1186/s13195-024-01621-6.
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本文引用的文献

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Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial.强化生活方式改变对阿尔茨海默病所致轻度认知障碍或早期痴呆进展的影响：一项随机对照临床试验。
Alzheimers Res Ther. 2024 Jun 7;16(1):122. doi: 10.1186/s13195-024-01482-z.
2
The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial.澳大利亚通过生活方式干预保护大脑健康降低痴呆风险的多领域方法研究（AU-ARROW）：一项单盲、多中心、随机对照试验的研究方案。
Alzheimers Dement (N Y). 2024 Apr 9;10(2):e12466. doi: 10.1002/trc2.12466. eCollection 2024 Apr-Jun.
3
Protocol for the Brain Health Support Program Study of the Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP): A Prospective 12-Month Intervention Study.《加拿大多领域干预预防痴呆症治疗平台试验的大脑健康支持计划研究方案》（CAN-THUMBS UP）：一项为期 12 个月的前瞻性干预研究。
J Prev Alzheimers Dis. 2023;10(4):875-885. doi: 10.14283/jpad.2023.65.
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Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER).研究设计和方法：美国通过生活方式干预保护大脑健康以降低风险的研究（美国指针研究）。
Alzheimers Dement. 2024 Feb;20(2):769-782. doi: 10.1002/alz.13365. Epub 2023 Sep 30.
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Dementia prevention, intervention, and care: 2020 report of the Lancet Commission.《痴呆症的预防、干预与照护：柳叶刀委员会2020年报告》
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