Kawaguchi E
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Apr;37(4):596-602.
An optical and electron microscopy evaluation of implantation sites of 7-9 week pregnancies was performed. The area of investigation was the basal plate and tissues extending both maternally and fetally. The progressive development of villous trophoblasts to cytotrophoblasts in the cell column to syncytiotrophoblasts, to free or "invasive" trophoblasts, and their relationships to the decidua and myometrium were studied. In the fibrinoid layer located between the maternal and fetal tissues are found trophoblasts with amoeboid extensions as well as those showing signs of degeneration. Also found are inflammatory cells of maternal origin and cellular debris. Deep in the fibrinoid layer, in the decidua, there are well developed round trophoblasts as well as some which invade the vascular lumens and replace the endothelial linings. Some of these invasive trophoblasts become polynuclear giant cells. These findings suggest that cytotrophoblasts which form the placental villi also actively invade maternal tissues, eliciting maternal immunologic responses, which result in the development of the fibrinoid layer or "Battle Zone", between the maternal and fetal tissues.
对7-9周妊娠的着床部位进行了光学显微镜和电子显微镜评估。研究区域为基底板以及向母体和胎儿延伸的组织。研究了绒毛滋养层细胞在细胞柱中向细胞滋养层细胞、合体滋养层细胞、游离或“侵袭性”滋养层细胞的逐步发育过程，以及它们与蜕膜和子宫肌层的关系。在母体和胎儿组织之间的纤维素样层中发现了具有阿米巴样延伸的滋养层细胞以及显示退化迹象的滋养层细胞。还发现了源自母体的炎性细胞和细胞碎片。在纤维素样层深处的蜕膜中，有发育良好的圆形滋养层细胞，还有一些侵入血管腔并取代内皮衬里的滋养层细胞。其中一些侵袭性滋养层细胞会变成多核巨细胞。这些发现表明，形成胎盘绒毛的细胞滋养层细胞也会积极侵入母体组织，引发母体免疫反应，从而导致母体和胎儿组织之间形成纤维素样层或“战斗区”。
