Dobashi K
Department of Obstetrics and Gynecology, Nikon University School of Medicine, Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 Apr;40(4):481-7.
This investigation of trophoblasts (Trs) in early gestation was performed by histologic and immunohistochemical evaluation of the Trs of the basal plate, decidua and myometrium, in an attempt to determine the changes in structure and function dependent on their location. The structural evaluation was performed by both light and electron microscopy and the functional evaluation by the localization of hCG, its subunits and hPL. In the syncytiotrophoblastic cell layer both hCG, its subunits and hPL are localized intracellularly. In the decidua, the so-called invasive Trs, only hPL could be detected. Histologically, the Trs in the deeper decidua tend to coalesce and become multinucleated. Thus, villous Trs and invasive Trs differ not only structurally, but also functionally, as can be seen by the differences in the synthesis of hCG and hPL, leading to the assumption that Trs have varying functions dependent upon their location.
本研究通过对基底板、蜕膜和子宫肌层的滋养层细胞进行组织学和免疫组织化学评估，对早期妊娠的滋养层细胞进行了研究，试图确定其结构和功能随位置变化的情况。结构评估通过光学显微镜和电子显微镜进行，功能评估通过人绒毛膜促性腺激素（hCG）及其亚基和人胎盘催乳素（hPL）的定位进行。在合体滋养层细胞层中，hCG及其亚基和hPL均定位于细胞内。在蜕膜中，即所谓的侵袭性滋养层细胞，仅能检测到hPL。组织学上，深层蜕膜中的滋养层细胞倾向于融合并形成多核。因此，绒毛滋养层细胞和侵袭性滋养层细胞不仅在结构上不同，在功能上也不同，这从hCG和hPL合成的差异中可以看出，由此推测滋养层细胞的功能因其位置而异。
