Gupta Ankita, Hall Matt, Masserano Benjamin, Wilson Averi, Johnson Katherine, Chen Clifford, Challa Lasya, Katragadda Harita, Mittal Vineeta
Department of Pediatrics, Division of Pediatric Hospital Medicine, University of Texas Southwestern, Dallas, Texas, USA.
Children's Medical Center, Dallas, Texas, USA.
J Hosp Med. 2025 Jul;20(7):710-726. doi: 10.1002/jhm.13597. Epub 2025 Feb 2.
Children with new-onset psychosis often require hospitalization for medical evaluation.
The goal of this study was to assess variations in the management of children with new-onset psychosis and characterize trends in resource utilization.
The study included index hospitalizations for children ages 7-18 admitted to children's hospitals with a primary diagnosis of psychosis from 2011 to 2022 using the Pediatric Health Information System (PHIS) database. Children with a complex chronic condition were excluded. Resource utilization categories included medication, imaging, laboratory, and other clinical resources. Variability in resource utilization was assessed using covariance tests for random intercepts with generalized linear modes after adjusting for age, sex, payor, and severity. Trends in resource utilization were examined using generalized estimating equations adjusting for the same factors and accounting for hospital clustering.
Our data set included 7126 new-onset psychosis hospitalizations from 37 children's hospitals. Teenage males and non-Hispanic Whites were most likely to be hospitalized. There was a significant variation in resource utilization across hospitals in all categories (p < .001). The most frequently utilized resources were antipsychotic medications (76%), serum chemistry (77%), toxicology labs (72%), and brain magnetic resonance imaging (22%). The most notable increases in utilization were in the performance of laboratory tests, brain imaging, anesthetic use, and intravenous immunoglobulin use.
Study findings suggest that there has been a stable rate of hospitalization for children with new-onset psychosis, yet a significant variation in the medical evaluation exists. Significant increases and variations in resource utilization across all categories suggest an emerging need for robust evidence and consensus-based practice guidelines.
初发精神病患儿通常需要住院进行医学评估。
本研究的目的是评估初发精神病患儿管理方面的差异,并描述资源利用趋势。
该研究纳入了2011年至2022年期间使用儿科健康信息系统(PHIS)数据库入住儿童医院、主要诊断为精神病的7至18岁儿童的索引住院病例。患有复杂慢性病的儿童被排除在外。资源利用类别包括药物、影像学、实验室及其他临床资源。在调整年龄、性别、付款方和严重程度后,使用随机截距协方差检验和广义线性模型评估资源利用的变异性。使用广义估计方程调整相同因素并考虑医院聚类,以研究资源利用趋势。
我们的数据集包括来自37家儿童医院的7126例初发精神病住院病例。青少年男性和非西班牙裔白人最有可能住院。所有类别中各医院的资源利用存在显著差异(p < 0.001)。最常使用的资源是抗精神病药物(76%)、血清化学检查(77%)、毒理学实验室检查(72%)和脑磁共振成像(22%)。利用率增加最为显著的是实验室检查、脑成像、麻醉使用和静脉注射免疫球蛋白的使用。
研究结果表明,初发精神病患儿的住院率稳定,但医学评估存在显著差异。所有类别中资源利用的显著增加和差异表明,迫切需要强有力的证据和基于共识的实践指南。