2023/2024年匈牙利一种新型人细小病毒B19基因型1（亚型1a2）变体的血清流行病学（2018 - 2024年）及疫情传播情况
Seroepidemiology (2018-2024) and epidemic spread of an emerging human parvovirus B19 genotype 1 (subtype 1a2) variant in Hungary, 2023/2024.
作者信息
Tóth Fruzsina, Moser Tímea, Boros Ákos, Balázs Benigna, Takáts Károly, Pankovics Péter, Reuter Gábor
机构信息
Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Szigeti út 12., Pécs, 7624, Hungary.
出版信息
Arch Virol. 2025 Feb 2;170(2):45. doi: 10.1007/s00705-025-06228-2.
An unusually large number of human parvovirus B19 (B19V) infections were reported in European countries in 2023/2024, but the genetic background of this B19V epidemic strain is unknown. In this study, there was a larger number of confirmed B19V infections (five in 2021, eight in 2023, and 59 in 2024) and higher IgG seroprevalence (41.4% in 2022 and 54.3% in 2024) in Transdanubia, Hungary, in 2024 compared to 2018-2023. A B19V genotype 1a2 variant (prototype, 1338/HUN/2024, PQ155933) with common and unique nucleotide insertions in the untranslated regions of the genome and nonsynonymous and synonymous mutations in the coding region (NS1 and VP1) could be responsible to the ongoing B19V epidemic in Europe.
2023/2024年欧洲国家报告了异常大量的人细小病毒B19（B19V）感染病例，但这种B19V流行毒株的基因背景尚不清楚。在本研究中，与2018 - 2023年相比，2024年匈牙利多瑙河以西地区确诊的B19V感染病例数量更多（2021年有5例，2023年有8例，2024年有59例），IgG血清阳性率更高（2022年为41.4%，2024年为54.3%）。一种B19V基因型1a2变体（原型，1338/HUN/2024，PQ155933）在基因组的非翻译区有常见和独特的核苷酸插入，在编码区（NS1和VP1）有非同义突变和同义突变，这可能是导致欧洲目前B19V疫情的原因。
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