Anand Varun, Rastogi Namrata
Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
J Org Chem. 2025 Feb 14;90(6):2479-2486. doi: 10.1021/acs.joc.4c03067. Epub 2025 Feb 2.
A mild and efficient protocol for the perhaloacylation of α-carbonyl sulfoxonium ylides has been developed. The commercially available perfluoro- and perchloroacid anhydrides were used as acylating agents in catalyst- and additive-free reactions to access α-carbonyl-α'-perhaloacyl sulfoxonium ylides in high yields. The reaction offers a simple method to prepare valuable polyfluorinated organosulfur molecules.
