Bao Xue-Ying, Liu Cun-Zhi, Qian Zi-Tong, Wang Lu, Tu Jian-Feng, Li Bin-Yan, Wang Xiao, Wan Fang, Li Zhi-Han, Liu Zhao-Yi, Ma Liang-Xiao, Wang Li-Qiong
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, China.
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, China; International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, China.
Complement Ther Med. 2025 May;89:103138. doi: 10.1016/j.ctim.2025.103138. Epub 2025 Jan 31.
Hypertension is often accompanied by anxiety and sleep disorders, which further complicate the disease. This study aimed to evaluate the feasibility and effectiveness of transcutaneous electrical acupoint stimulation (TEAS) in patients with hypertension and anxiety or sleep disorders.
Eligible participants were randomly assigned to the 10 Hz TEAS, 2 Hz TEAS, or routine treatment groups in a 1:1:1 ratio. Participants continued their routine treatment during the trial, while those in the two TEAS groups received 12 sessions of 30-min TEAS treatment with different stimulation frequencies. The feasibility parameters were successful screening probability, enrollment rate, and dropout rate. The primary outcome was the change in office systolic blood pressure from baseline to week four. Secondary outcomes included changes in office diastolic blood pressure, heart rate, Pittsburgh Sleep Quality Index score, and Generalized Anxiety Disorder 7-item scale score from baseline to week four.
Eighty-eight participants (age 58.0 [51.0, 63.0] years; 49 women) were randomized. The successful screening probability was 56.1 %, the enrollment rate was 3.1 participants per week, and the dropout rate was 14.8 %. The change in office systolic blood pressure from baseline to week four was -2.8 ± 13.6 mm Hg, -6.4 ± 10.0 mm Hg, and -7.2 ± 11.2 mm Hg, respectively, in the 10 Hz TEAS, 2 Hz TEAS, and routine treatment groups (P = 0.332). No significant differences were noted, except for a change in the Pittsburgh Sleep Quality Index score (P = 0.014). Both 10 Hz (P = 0.024) and 2 Hz TEAS (P = 0.039) significantly improved sleep quality compared to routine treatment.
In patients with hypertension having anxiety or sleep disorders, this study did not demonstrate the superiority of TEAS over routine treatment but did show an improvement in sleep quality and a downward trend in diastolic blood pressure. Therefore, a largescale trial is warranted.
高血压常伴有焦虑和睡眠障碍，这使病情进一步复杂化。本研究旨在评估经皮穴位电刺激（TEAS）对高血压合并焦虑或睡眠障碍患者的可行性和有效性。
符合条件的参与者按1:1:1的比例随机分配至10Hz TEAS组、2Hz TEAS组或常规治疗组。试验期间，参与者继续其常规治疗，而两个TEAS组的参与者接受12次、每次30分钟、不同刺激频率的TEAS治疗。可行性参数为成功筛查概率、入组率和退出率。主要结局是从基线到第4周诊室收缩压的变化。次要结局包括从基线到第4周诊室舒张压、心率、匹兹堡睡眠质量指数评分和广泛性焦虑障碍7项量表评分的变化。
88名参与者（年龄58.0[51.0,63.0]岁；49名女性）被随机分组。成功筛查概率为56.1%，入组率为每周3.1名参与者，退出率为14.8%。10Hz TEAS组、2Hz TEAS组和常规治疗组从基线到第4周诊室收缩压的变化分别为-2.8±13.6mmHg、-6.4±10.0mmHg和-7.2±11.2mmHg（P=0.332）。除匹兹堡睡眠质量指数评分有变化外（P=0.014），未观察到显著差异。与常规治疗相比，10Hz（P=0.024）和2Hz TEAS（P=0.039）均显著改善了睡眠质量。
在患有焦虑或睡眠障碍的高血压患者中，本研究未证明TEAS优于常规治疗，但确实显示出睡眠质量有所改善且舒张压呈下降趋势。因此，有必要进行大规模试验。
