Future of Sleep Medicine: Novel Insights on Sleep Regulation from Network Physiology (Part II).

The authors review recent progress in understanding fundamental aspects of physiologic regulation during wake and sleep based on modern data-driven, analytic, and computational approaches with focus on the complex dynamics of physiologic systems interactions, their coexisting and transient forms of coupling, and the role of network integration among physiologic systems in generating states and functions at the organism level. They underscore the importance of novel network-based integrative approaches and the network physiology framework to investigate the structure and dynamics of physiologic networks and to quantify emergent global states and behaviors in health and disease.