Ivanov Plamen Ch, Bartsch Ronny P
Keck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, MA 02215, USA; Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia 1784, Bulgaria.
Department of Physics, Bar-Ilan University, Ramat Gan 5290002, Israel.
Sleep Med Clin. 2025 Mar;20(1):149-164. doi: 10.1016/j.jsmc.2024.10.013. Epub 2024 Nov 26.
The authors review recent progress in understanding fundamental aspects of physiologic regulation during wake and sleep based on modern data-driven, analytic, and computational approaches with focus on the complex dynamics of physiologic systems interactions, their coexisting and transient forms of coupling, and the role of network integration among physiologic systems in generating states and functions at the organism level. They underscore the importance of novel network-based integrative approaches and the network physiology framework to investigate the structure and dynamics of physiologic networks and to quantify emergent global states and behaviors in health and disease.
作者基于现代数据驱动、分析和计算方法，回顾了在理解清醒和睡眠期间生理调节基本方面的最新进展，重点关注生理系统相互作用的复杂动态、它们共存和瞬态的耦合形式，以及生理系统之间的网络整合在机体水平产生状态和功能中的作用。他们强调了基于网络的新型整合方法和网络生理学框架对于研究生理网络的结构和动态，以及量化健康和疾病中出现的全局状态和行为的重要性。
