Ivanov Plamen Ch, Bartsch Ronny P
Keck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, MA 02215, USA; Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia 1784, Bulgaria.
Department of Physics, Bar-Ilan University, Ramat Gan 5290002, Israel.
Sleep Med Clin. 2025 Mar;20(1):135-148. doi: 10.1016/j.jsmc.2024.10.010. Epub 2024 Dec 10.
We review recent progress in understanding fundamental aspects of physiologic regulation during wake and sleep based on modern data-driven, analytical, and computational approaches with a focus on the complex dynamics of individual physiologic systems. The presented empirical findings indicate that sleep-wake and circadian cycles do not simply modulate basic physiologic functions but influence physiologic systems dynamics simultaneously over a broad range of time scales. The reviewed empirical approaches and derived measures represent novel mechanistic aspects of sleep and wake regulation, and lay the foundation for a new class of diagnostic and prognostic biomarkers in clinical sleep medicine.
我们基于现代数据驱动、分析和计算方法，回顾了在理解清醒和睡眠期间生理调节基本方面的最新进展，重点关注个体生理系统的复杂动态。所呈现的实证研究结果表明，睡眠-清醒和昼夜节律周期不仅仅调节基本生理功能，还会在广泛的时间尺度上同时影响生理系统的动态。所回顾的实证方法和衍生指标代表了睡眠和清醒调节的新机制方面，并为临床睡眠医学中的一类新型诊断和预后生物标志物奠定了基础。
