Ji Ki-Hwan, Yun Chang-Ho
Department of Neurology, Inje University Busan Paik Hospital, College of Medicine, Inje University, 75 Bokjiro, Busanjin-gu, Busan 47392, Republic of Korea.
Deparment of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, 82 Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, Gyeonggi 13620, Republic of Korea.
Sleep Med Clin. 2025 Mar;20(1):47-55. doi: 10.1016/j.jsmc.2024.10.011. Epub 2024 Dec 7.
This review explores cutting-edge advancements, including wearable sleep trackers, brain age assessments, transcranial electrical stimulation (TES), acoustic stimulation, and glymphatic system modulation. Sleep trackers provide continuous monitoring of sleep patterns, while brain age estimation offers insights into brain health and early detection of accelerated aging. TES shows promise in improving mood, memory, and sleep. Acoustic stimulation during slow-wave sleep has been demonstrated to enhance memory consolidation. Additionally, optimizing the glymphatic system may facilitate brain waste clearance, crucial in preventing neurodegenerative diseases like Alzheimer's. However, significant challenges remain, including the need for rigorous longitudinal studies to validate these technologies' efficacy and safety.
本综述探讨了前沿进展，包括可穿戴睡眠追踪器、脑龄评估、经颅电刺激（TES）、声学刺激和淋巴系统调节。睡眠追踪器可对睡眠模式进行持续监测，而脑龄估计有助于了解脑健康状况并早期发现加速衰老。经颅电刺激在改善情绪、记忆和睡眠方面显示出前景。慢波睡眠期间的声学刺激已被证明可增强记忆巩固。此外，优化淋巴系统可能有助于清除脑内废物，这对预防如阿尔茨海默病等神经退行性疾病至关重要。然而，仍存在重大挑战，包括需要进行严格的纵向研究以验证这些技术的有效性和安全性。
