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POLE Mutation Associated With Microsatellite Instability and High Tumor Mutational Burden Confers Exquisite Sensitivity to Immune Checkpoint Inhibitor Therapy in Non-Small Cell Lung Cancer: A Case Report and Genomic Database Analysis.

作者信息

Lara Matthew S, Riess Jonathan W, Kaleka Guneet, Borowsky Alexander, McPherson John D, Godoy Luis A, Grego Lorenzo, Lara Primo N, Mitsiades Nicholas

机构信息

ARC-MD Program, UC Davis School of Medicine, Sacramento, CA.

Davis Comprehensive Cancer Center, University of California (UC), Sacramento, CA.

出版信息

Clin Lung Cancer. 2025 May;26(3):e207-e213. doi: 10.1016/j.cllc.2025.01.005. Epub 2025 Jan 8.

DOI:10.1016/j.cllc.2025.01.005
PMID:39894709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12230208/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a478/12230208/8aa0570915ca/nihms-2073785-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a478/12230208/cdc95e453eb7/nihms-2073785-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a478/12230208/ac425969dd5a/nihms-2073785-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a478/12230208/8aa0570915ca/nihms-2073785-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a478/12230208/cdc95e453eb7/nihms-2073785-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a478/12230208/ac425969dd5a/nihms-2073785-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a478/12230208/8aa0570915ca/nihms-2073785-f0003.jpg

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本文引用的文献

1
Perioperative Nivolumab in Resectable Lung Cancer.可切除肺癌的围手术期纳武利尤单抗。
N Engl J Med. 2024 May 16;390(19):1756-1769. doi: 10.1056/NEJMoa2311926.
2
Cancer statistics, 2024.2024年癌症统计数据。
CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49. doi: 10.3322/caac.21820. Epub 2024 Jan 17.
3
Tumor mutational burden as a predictive biomarker for non-small cell lung cancer treated with immune checkpoint inhibitors of PD-1/PD-L1.肿瘤突变负荷作为 PD-1/PD-L1 免疫检查点抑制剂治疗非小细胞肺癌的预测生物标志物。
Clin Transl Oncol. 2024 Jun;26(6):1446-1458. doi: 10.1007/s12094-023-03370-8. Epub 2024 Jan 8.
4
Integrating POLE/POLD1 mutated for immunotherapy treatment planning of advanced stage non-small cell lung cancer.将 POLE/POLD1 突变整合用于晚期非小细胞肺癌的免疫治疗计划。
Thorac Cancer. 2023 Aug;14(23):2269-2274. doi: 10.1111/1759-7714.15012. Epub 2023 Jun 22.
5
Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis.在接受 1L 免疫检查点抑制剂治疗的 TMB 升高的晚期 NSCLC 中具有持久应答者：真实世界的结果分析。
J Immunother Cancer. 2023 Jan;11(1). doi: 10.1136/jitc-2022-005801.
6
POLE/POLD1 mutation and tumor immunotherapy.POLE/POLD1 突变与肿瘤免疫治疗。
J Exp Clin Cancer Res. 2022 Jul 2;41(1):216. doi: 10.1186/s13046-022-02422-1.
7
Clinical and Molecular Characterization of Mutations as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Cancers.基因突变的临床和分子特征可作为预测晚期癌症免疫检查点抑制剂疗效的生物标志物。
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DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells.DNA 聚合酶和错配修复在正常和恶性人类细胞中产生不同的微卫星不稳定性特征。
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Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε.DNA 聚合酶 ε 中最常发生的与癌症相关取代的结构后果。
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