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一例伴有罕见广泛多骨型纤维发育不良的McCune-Albright综合征病例。

A Case of McCune Albright Syndrome With Rare Extensive Polyostotic Fibrous Dysplasia.

作者信息

Ganesan Harinee, Madivanane Vasanth, Dhayalane Kabilash, Sainath Ragire, Goyal Harish

机构信息

Department of Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical Education Research, Puducherry, India.

出版信息

Clin Nucl Med. 2025 Jul 1;50(7):e433-e434. doi: 10.1097/RLU.0000000000005674. Epub 2025 Feb 3.

Abstract

McCune-Albright syndrome is characterized by a triad of café au lait macules, polyostotic fibrous dysplasia (FD), and endocrine abnormalities. Bilateral and extensive presentation of FD is rarely reported. We report an interesting case of 24-year-old woman presenting with multiple episodes of slip and fall, sustaining multiple fractures with history of precocious puberty and skin complaints. On evaluation with 99m Tc-MDP bone scan, all the long bones, ribs, pelvic bones, frontal bone, and maxilla showed deformities and increased osteoblastic activity, suggesting extensive polyostotic FD. Thus emphasizing the crucial role of 99m Tc-MDP bone scan in the diagnosis of extensive FD and guides in understanding of the polyostotic involvement.

摘要

McCune-Albright综合征的特征为三联征,即咖啡斑、多骨型纤维发育不良(FD)和内分泌异常。FD双侧广泛受累的情况鲜有报道。我们报告了一例有趣的病例,一名24岁女性,有多次滑倒和跌倒史,因性早熟和皮肤问题有多处骨折。经99m锝-亚甲基二膦酸盐(99m Tc-MDP)骨扫描评估,所有长骨、肋骨、骨盆骨、额骨和上颌骨均显示畸形且成骨活性增加,提示广泛的多骨型FD。这凸显了99m Tc-MDP骨扫描在广泛FD诊断中的关键作用,并有助于理解多骨受累情况。

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