Bonciani D, Della Bella C, Corrà A, Galano A, Vaggelli G, Tapinassi S, Grassi A, Mantengoli E, Coi A, Quintarelli L, Mariotti E B, Aimo C, Ruffo di Calabria V, Garufi E, Volpi V, Verdelli A, Rossolini G M, Bartoloni A, D'Elios M M, Caproni M
Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
J Dermatol. 2025 Mar;52(3):432-438. doi: 10.1111/1346-8138.17645. Epub 2025 Feb 3.
The association between psoriasis and streptococcal infection has been widely explored in both children and adults. However, the exact impact of Streptococcus pharyngeal infection on the course of psoriasis is not fully comprehended. This study explored the impact of Streptococcus pharyngeal infection on psoriasis and investigated the effectiveness of systemic antibiotic therapy in conjunction with standard topical treatment for psoriatic patients with concomitant streptococcal throat infection. The research involved 115 patients with mild-to-moderate psoriasis, clinically assessed using the Psoriasis Area and Severity Index (PASI). Patients with active streptococcal infection were administered adjunctive systemic antibiotic therapy along with standard local treatment for psoriasis, while psoriasis patients without evidence of infection received the local topical treatment only. Streptococcal infections were more common in psoriasis patients compared to healthy controls. A group of psoriasis patients with active streptococcal throat infections, treated with antibiotics in addition to standard topical psoriasis therapy, did not show any difference in PASI score reduction compared to those without evidence of active infection. While our study did not show a statistically significant reduction in PASI scores in psoriasis patients with streptococcal throat infections treated with antibiotics, it highlights the complex interaction between infection and psoriasis. Larger studies with longer follow-up may better clarify this relationship, contributing to stronger evidence for or against the use of antibiotics in managing psoriasis triggered by streptococcal infections.
银屑病与链球菌感染之间的关联已在儿童和成人中得到广泛研究。然而，咽部链球菌感染对银屑病病程的确切影响尚未完全明了。本研究探讨了咽部链球菌感染对银屑病的影响，并研究了全身抗生素治疗联合标准局部治疗对伴有链球菌性咽喉感染的银屑病患者的有效性。该研究纳入了115例轻至中度银屑病患者，采用银屑病面积和严重程度指数（PASI）进行临床评估。活动性链球菌感染的患者在接受银屑病标准局部治疗的同时，还接受了辅助性全身抗生素治疗，而无感染证据的银屑病患者仅接受局部治疗。与健康对照相比，银屑病患者中链球菌感染更为常见。一组伴有活动性链球菌性咽喉感染的银屑病患者，在接受标准银屑病局部治疗的同时加用抗生素治疗，与无活动性感染证据的患者相比，PASI评分降低无差异。虽然我们的研究未显示抗生素治疗的链球菌性咽喉感染的银屑病患者PASI评分有统计学意义的降低，但它突出了感染与银屑病之间复杂的相互作用。进行更长随访期的更大规模研究可能会更好地阐明这种关系，为支持或反对使用抗生素治疗由链球菌感染引发的银屑病提供更有力的证据。
