Department of Dermatology, Far Eastern Memorial Hospital , New Taipei , Taiwan.
Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei , Taiwan.
Expert Rev Clin Pharmacol. 2019 Oct;12(10):981-989. doi: 10.1080/17512433.2019.1665027. Epub 2019 Sep 30.
: Psoriasis is affected by many environmental factors, including infections and antibiotics. However, the relationship between antibiotics and psoriasis is inadequately studied. Some antibiotics were listed as triggering factors; others showed benefit for psoriasis control. The aim of this article is to review current evidence that may help identify appropriate antibiotics for patients with psoriasis. : The PubMed, Embase, Clinicalkey databases, and google scholar were searched for relevant articles published up to May 2019. Literature regarding antibiotics and psoriasis were included. Six randomized controlled trials and four controlled or cohort studies were identified in 13 kinds of antibiotics. : Macrolides and rifampin showed decrease of psoriasis area and severity index score in plaque-type psoriasis, while penicillin revealed no statistically significant improvement in guttate psoriasis. Previously tetracyclines were considered as triggering factors, but data were found only in cases or retrospective studies. Mechanisms were thought to be related to immunomodulation rather than bacteria inhibition. Research gap in the influence of genetic susceptibility, the impact on microbiota, and the mode of actions remain to be investigated.
: 银屑病受多种环境因素影响，包括感染和抗生素。然而，抗生素与银屑病之间的关系尚未得到充分研究。一些抗生素被列为触发因素；另一些则显示出对银屑病控制有益。本文旨在综述现有证据，以期为银屑病患者识别合适的抗生素。: 检索了截至 2019 年 5 月的 PubMed、Embase、Clinicalkey 数据库和谷歌学术上关于抗生素和银屑病的相关文献。纳入了关于抗生素和银屑病的文献。在 13 种抗生素中确定了 6 项随机对照试验和 4 项对照或队列研究。: 大环内酯类和利福平可降低斑块型银屑病的银屑病面积和严重程度指数评分，而青霉素对点滴状银屑病的改善无统计学意义。先前认为四环素类药物是触发因素，但仅在病例或回顾性研究中发现相关数据。作用机制被认为与免疫调节有关，而不是抑制细菌。遗传易感性、对微生物组的影响以及作用方式的研究空白仍有待探索。
