Choi Eung Ho
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Allergy Asthma Immunol Res. 2025 Jan;17(1):32-46. doi: 10.4168/aair.2025.17.1.32.
This review focuses on the skin barrier function in neonates and infants, emphasizing the structural and functional differences compared to adult skin. Neonatal and infant skin is thinner, more permeable, and less developed, which makes it more vulnerable to irritants, infections, and dehydration. Additionally, the critical role of skin pH in maintaining barrier function is discussed, noting significant changes in pH levels during early life. This review also examines the relationship between the onset of atopic dermatitis and skin barrier function, underscoring the importance of maintaining skin barrier integrity from birth to reduce the risk of atopic diseases. Finally, recommendations are offered for skincare practices in neonates and infants, emphasizing the use of mild, fragrance-free products and the importance of tailoring skincare regimens to meet the specific needs of each neonate or infant.
本综述聚焦于新生儿和婴儿的皮肤屏障功能，着重阐述其与成人皮肤在结构和功能上的差异。新生儿和婴儿的皮肤更薄、渗透性更强且发育程度较低，这使其更容易受到刺激物、感染和脱水的影响。此外，还讨论了皮肤pH值在维持屏障功能中的关键作用，并指出生命早期pH水平的显著变化。本综述还研究了特应性皮炎的发病与皮肤屏障功能之间的关系，强调从出生起维持皮肤屏障完整性对于降低特应性疾病风险的重要性。最后，针对新生儿和婴儿的皮肤护理实践提出了建议，强调使用温和、无香料的产品以及根据每个新生儿或婴儿的具体需求定制皮肤护理方案的重要性。
