Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Clin Dermatol. 2019 Jul-Aug;37(4):336-345. doi: 10.1016/j.clindermatol.2019.04.009. Epub 2019 Apr 26.
The skin barrier is mainly present in the stratum corneum (SC), composed of corneocytes surrounded by intercellular lipid lamellae, and attached by corneodesmosome. The tight junction attached to the lateral walls of keratinocytes in the upper part of the stratum granulosum is also included in the skin barrier. During aging, the following structures and functions of the skin barrier are changed or disturbed: (1) skin barrier structure, (2) permeability barrier function, (3) epidermal calcium gradient, (4) epidermal lipid synthesis and SC lipid processing, (5) cytokine production and response after insults, (6) SC acidity, (7) SC hydration, and (8) antimicrobial barrier. Patients with diabetes also show changes in the skin barrier similar to those in aged skin, and the characteristics of the skin barrier are very similar. Understanding the pathogenic mechanisms of the skin barrier in aging will permit us to develop therapeutic strategies for aged or diabetic skin.
皮肤屏障主要存在于角质层 (SC) 中，由细胞间脂质板包围的角质形成细胞组成，并通过角质桥粒连接。在上层颗粒层的角朊细胞的侧壁上连接的紧密连接也包含在皮肤屏障中。在衰老过程中，皮肤屏障的以下结构和功能发生改变或受到干扰：（1）皮肤屏障结构，（2）通透性屏障功能，（3）表皮钙梯度，（4）表皮脂质合成和 SC 脂质处理，（5）损伤后的细胞因子产生和反应，（6）SC 酸度，（7）SC 水合作用，和（8）抗菌屏障。糖尿病患者的皮肤屏障也会发生类似于老年皮肤的变化，并且皮肤屏障的特征非常相似。了解皮肤屏障在衰老过程中的发病机制，将使我们能够为衰老或糖尿病皮肤开发治疗策略。
