慢性乙醇处理后大鼠小脑脂质的情况

Cerebellum lipids in rats after chronic ethanol treatment.

作者信息

Vrbaski S R, Ristić M

出版信息

J Neurochem. 1985 Jun;44(6):1868-72. doi: 10.1111/j.1471-4159.1985.tb07181.x.

DOI:10.1111/j.1471-4159.1985.tb07181.x

Abstract

Eighteen male Wistar rats weighing approximately 200 g were divided into three groups of six animals each. The experimental animals were maintained on nutritionally complete diets in which ethanol comprised 45% of the available energy. Control animals were pair-fed an equivalent diet in which sucrose was substituted isocalorically for ethanol. An additional control group received unlimited access to standard pelleted laboratory food and water. The investigations were carried out over 24 weeks. The effects on phospholipid, monogalactosyl glycolipid, and ganglioside composition after 24 weeks of feeding 43% alcohol were studied. There is abundant evidence that the changes in the cerebellum membrane phospholipids (phosphatidylethanolamine and phosphatidylcholine), gangliosides (GT1b), and myelin lipids (phosphatidylserine, sphingophospholipid, phosphatidylinositol, cerebrosides with hydroxy fatty acids, sulfoglycolipids, and monosialoganglioside GM1) occur as a result of chronic ethanol treatment.

摘要

18只体重约200克的雄性Wistar大鼠被分为三组，每组6只。实验动物喂食营养完全的饮食，其中乙醇提供45%的可用能量。对照动物成对喂食等量饮食，其中蔗糖等热量替代乙醇。另一个对照组可随意获取标准颗粒状实验室食物和水。研究持续24周。研究了喂食43%酒精24周后对磷脂、单半乳糖基糖脂和神经节苷脂组成的影响。有充分证据表明，慢性乙醇处理会导致小脑膜磷脂（磷脂酰乙醇胺和磷脂酰胆碱）、神经节苷脂（GT1b）和髓磷脂脂质（磷脂酰丝氨酸、鞘磷脂、磷脂酰肌醇、含羟基脂肪酸的脑苷脂、硫糖脂和单唾液酸神经节苷脂GM1）发生变化。