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儿童咀嚼型维生素补充剂的侵蚀潜力:一项体外研究。

Erosive potential of children's chewable vitamin supplements: An in vitro investigation.

作者信息

Lertsooksawat Wannee, Tanjaruphan Yanisa, Chaima Thanawat, Lerdpibulchai Thanawat, Wittayathawornwong Tanawan, Teanchai Chayada, Surarit Rudee, Horsophonphong Sivaporn

机构信息

Department of Pharmacology, Faculty of Dentistry, Mahidol University, Thailand.

Undergraduate Program, Faculty of Dentistry, Mahidol University, Thailand.

出版信息

J Dent Res Dent Clin Dent Prospects. 2024 Fall;18(4):278-283. doi: 10.34172/joddd.41791. Epub 2024 Dec 14.

Abstract

BACKGROUND

Chewable vitamins are dietary supplements in which vitamins are combined with a flavor that appeals to children. The acidic nature of some vitamins and some flavoring agents may cause dental erosion. We investigated the effect of children's chewable vitamin supplements on the loss of minerals in teeth.

METHODS

Forty-two human tooth enamel samples were prepared and randomly assigned to seven groups (n=6). Six groups contained different chewable vitamin tablets dissolved in deionized water, and a control group contained only deionized water. Each tablet was ground before its dissolution, and its pH was measured. Each tooth sample was immersed in a vitamin solution and artificial saliva in periodic cycles for 14 days. Each sample was weighed before and after immersion to calculate its weight loss percentage. Scanning electron microscopy was used to investigate the morphology of the enamel surfaces. For statistical analysis, the weight loss percentages between groups were compared using Welch's ANOVA, followed by post hoc Dunnett's T3 analysis (<0.05).

RESULTS

All the tested supplements were acidic, with a pH range of 2.99‒4.77. Most of the vitamin groups tested led to significant weight loss; it was greater for the vitamin C groups than the multivitamin groups. Scanning electron microscopy revealed erosion and destruction of enamel surfaces following vitamin exposure.

CONCLUSION

All the chewable vitamin supplements were acidic, with the majority potentially eroding enamel. The erosive potential was less pronounced in vitamin supplements containing minerals.

摘要

背景

咀嚼型维生素是一种膳食补充剂,其中维生素与受儿童喜爱的口味相结合。某些维生素和一些调味剂的酸性性质可能会导致牙齿侵蚀。我们研究了儿童咀嚼型维生素补充剂对牙齿矿物质流失的影响。

方法

制备42个人类牙釉质样本,并随机分为七组(n = 6)。六组含有溶解在去离子水中的不同咀嚼型维生素片,对照组仅含有去离子水。每片在溶解前研磨,并测量其pH值。每个牙齿样本在维生素溶液和人工唾液中周期性浸泡14天。浸泡前后对每个样本称重以计算其重量损失百分比。使用扫描电子显微镜研究牙釉质表面的形态。为进行统计分析,使用韦尔奇方差分析比较组间的重量损失百分比,随后进行事后邓尼特T3分析(<0.05)。

结果

所有测试的补充剂均呈酸性,pH范围为2.99‒4.77。大多数测试的维生素组导致显著的重量损失;维生素C组比多种维生素组的损失更大。扫描电子显微镜显示维生素暴露后牙釉质表面的侵蚀和破坏。

结论

所有咀嚼型维生素补充剂均呈酸性,大多数可能会侵蚀牙釉质。含矿物质的维生素补充剂的侵蚀潜力较小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/ade507976d79/joddd-18-278-g001.jpg

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