• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

儿童咀嚼型维生素补充剂的侵蚀潜力:一项体外研究。

Erosive potential of children's chewable vitamin supplements: An in vitro investigation.

作者信息

Lertsooksawat Wannee, Tanjaruphan Yanisa, Chaima Thanawat, Lerdpibulchai Thanawat, Wittayathawornwong Tanawan, Teanchai Chayada, Surarit Rudee, Horsophonphong Sivaporn

机构信息

Department of Pharmacology, Faculty of Dentistry, Mahidol University, Thailand.

Undergraduate Program, Faculty of Dentistry, Mahidol University, Thailand.

出版信息

J Dent Res Dent Clin Dent Prospects. 2024 Fall;18(4):278-283. doi: 10.34172/joddd.41791. Epub 2024 Dec 14.

DOI:10.34172/joddd.41791
PMID:39895684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11786007/
Abstract

BACKGROUND

Chewable vitamins are dietary supplements in which vitamins are combined with a flavor that appeals to children. The acidic nature of some vitamins and some flavoring agents may cause dental erosion. We investigated the effect of children's chewable vitamin supplements on the loss of minerals in teeth.

METHODS

Forty-two human tooth enamel samples were prepared and randomly assigned to seven groups (n=6). Six groups contained different chewable vitamin tablets dissolved in deionized water, and a control group contained only deionized water. Each tablet was ground before its dissolution, and its pH was measured. Each tooth sample was immersed in a vitamin solution and artificial saliva in periodic cycles for 14 days. Each sample was weighed before and after immersion to calculate its weight loss percentage. Scanning electron microscopy was used to investigate the morphology of the enamel surfaces. For statistical analysis, the weight loss percentages between groups were compared using Welch's ANOVA, followed by post hoc Dunnett's T3 analysis (<0.05).

RESULTS

All the tested supplements were acidic, with a pH range of 2.99‒4.77. Most of the vitamin groups tested led to significant weight loss; it was greater for the vitamin C groups than the multivitamin groups. Scanning electron microscopy revealed erosion and destruction of enamel surfaces following vitamin exposure.

CONCLUSION

All the chewable vitamin supplements were acidic, with the majority potentially eroding enamel. The erosive potential was less pronounced in vitamin supplements containing minerals.

摘要

背景

咀嚼型维生素是一种膳食补充剂,其中维生素与受儿童喜爱的口味相结合。某些维生素和一些调味剂的酸性性质可能会导致牙齿侵蚀。我们研究了儿童咀嚼型维生素补充剂对牙齿矿物质流失的影响。

方法

制备42个人类牙釉质样本,并随机分为七组(n = 6)。六组含有溶解在去离子水中的不同咀嚼型维生素片,对照组仅含有去离子水。每片在溶解前研磨,并测量其pH值。每个牙齿样本在维生素溶液和人工唾液中周期性浸泡14天。浸泡前后对每个样本称重以计算其重量损失百分比。使用扫描电子显微镜研究牙釉质表面的形态。为进行统计分析,使用韦尔奇方差分析比较组间的重量损失百分比,随后进行事后邓尼特T3分析(<0.05)。

结果

所有测试的补充剂均呈酸性,pH范围为2.99‒4.77。大多数测试的维生素组导致显著的重量损失;维生素C组比多种维生素组的损失更大。扫描电子显微镜显示维生素暴露后牙釉质表面的侵蚀和破坏。

结论

所有咀嚼型维生素补充剂均呈酸性,大多数可能会侵蚀牙釉质。含矿物质的维生素补充剂的侵蚀潜力较小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/98c4f97780a4/joddd-18-278-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/ade507976d79/joddd-18-278-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/298dbb7feaff/joddd-18-278-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/df93e2ce7bae/joddd-18-278-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/98c4f97780a4/joddd-18-278-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/ade507976d79/joddd-18-278-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/298dbb7feaff/joddd-18-278-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/df93e2ce7bae/joddd-18-278-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2838/11786007/98c4f97780a4/joddd-18-278-g004.jpg

相似文献

1
Erosive potential of children's chewable vitamin supplements: An in vitro investigation.儿童咀嚼型维生素补充剂的侵蚀潜力:一项体外研究。
J Dent Res Dent Clin Dent Prospects. 2024 Fall;18(4):278-283. doi: 10.34172/joddd.41791. Epub 2024 Dec 14.
2
Erosive potential of vitamin and vitamin+mineral effervescent tablets.维生素及维生素加矿物质泡腾片的侵蚀性潜力。
Swiss Dent J. 2016;126(5):457-465. doi: 10.61872/sdj-2016-05-01.
3
Erosive potential of vitamin waters, herbal drinks, carbonated soft drinks, and fruit juices on human teeth: An in vitro investigation.维生素水、草本饮料、碳酸软饮料和果汁对人牙齿的侵蚀潜力:一项体外研究。
J Dent Res Dent Clin Dent Prospects. 2023 Summer;17(3):129-135. doi: 10.34172/joddd.2023.40413. Epub 2023 Nov 11.
4
Evaluation of the impact of acidic medications and fluoride-containing mouthwash on the enamel surface using quantitative light-induced fluorescence, microhardness, and scanning electron microscopy: an in vitro study.使用定量光诱导荧光、显微硬度和扫描电子显微镜评估酸性药物和含氟漱口水对牙釉质表面的影响:一项体外研究。
BMC Oral Health. 2025 Jan 27;25(1):141. doi: 10.1186/s12903-025-05523-3.
5
In vitro assessment of dental erosion caused by clear aligners.体外评估隐形矫治器引起的牙齿酸蚀。
J Mech Behav Biomed Mater. 2024 Apr;152:106390. doi: 10.1016/j.jmbbm.2024.106390. Epub 2024 Jan 14.
6
Vitamin E: A potential preventive approach against dental erosion-an in vitro short-term erosive study.维生素 E:一种潜在的预防牙酸蚀症的方法——一项体外短期酸蚀研究。
J Dent. 2021 Oct;113:103781. doi: 10.1016/j.jdent.2021.103781. Epub 2021 Aug 13.
7
Erosive effects of commercially available alcoholic beverages on enamel.市售含酒精饮料对牙釉质的侵蚀作用。
Dent Mater J. 2023 Mar 30;42(2):236-240. doi: 10.4012/dmj.2022-155. Epub 2023 Jan 7.
8
Performance of a newly developed mineral gel system on erosive and erosive/abrasive enamel loss. An in vitro study.一种新开发的矿物凝胶系统对侵蚀性和侵蚀/磨蚀性牙釉质丧失的作用:一项体外研究
Swiss Dent J. 2018 Oct 15;128(10):790-797. doi: 10.61872/sdj-2018-10-443. Epub 2018 Aug 13.
9
Can the combination of proanthocyanidin and vitamin E or palm oil effectively protect enamel against in vitro erosive and abrasive challenges?原花青素和维生素 E 或棕榈油的联合使用能否有效保护牙釉质免受体外侵蚀和磨损的挑战?
J Appl Oral Sci. 2024 Jul 22;32:e20240100. doi: 10.1590/1678-7757-2024-0100. eCollection 2024.
10
Protocol for measurement of enamel loss from brushing with an anti-erosive toothpaste after an acidic episode.酸性发作后使用抗侵蚀牙膏刷牙导致牙釉质流失的测量方案。
Gen Dent. 2017 Jul-Aug;65(4):63-68.

本文引用的文献

1
Use of dietary supplements by children and adolescents.儿童和青少年使用膳食补充剂。
J Pediatr (Rio J). 2024 Mar-Apr;100 Suppl 1(Suppl 1):S31-S39. doi: 10.1016/j.jped.2023.09.008. Epub 2023 Oct 28.
2
Erosive potential of vitamin waters, herbal drinks, carbonated soft drinks, and fruit juices on human teeth: An in vitro investigation.维生素水、草本饮料、碳酸软饮料和果汁对人牙齿的侵蚀潜力:一项体外研究。
J Dent Res Dent Clin Dent Prospects. 2023 Summer;17(3):129-135. doi: 10.34172/joddd.2023.40413. Epub 2023 Nov 11.
3
A Global Overview of Dietary Supplements: Regulation, Market Trends, Usage during the COVID-19 Pandemic, and Health Effects.
膳食补充剂的全球概述:监管、市场趋势、在 COVID-19 大流行期间的使用情况以及健康影响。
Nutrients. 2023 Jul 26;15(15):3320. doi: 10.3390/nu15153320.
4
Dietary Supplement Use in Children and Adolescents Aged ≤19 Years - United States, 2017-2018.儿童和青少年(≤19 岁)中膳食补充剂的使用情况 - 美国,2017-2018 年。
MMWR Morb Mortal Wkly Rep. 2020 Oct 30;69(43):1557-1562. doi: 10.15585/mmwr.mm6943a1.
5
Alleviation of ascorbic acid-induced gastric high acidity by calcium ascorbate and .抗坏血酸钙缓解抗坏血酸诱导的胃高酸度及…… (原文此处不完整)
Korean J Physiol Pharmacol. 2018 Jan;22(1):35-42. doi: 10.4196/kjpp.2018.22.1.35. Epub 2017 Dec 22.
6
Citric acid: emerging applications of key biotechnology industrial product.柠檬酸:关键生物技术工业产品的新兴应用
Chem Cent J. 2017 Mar 8;11:22. doi: 10.1186/s13065-017-0251-y. eCollection 2017.
7
Erosive potential of vitamin and vitamin+mineral effervescent tablets.维生素及维生素加矿物质泡腾片的侵蚀性潜力。
Swiss Dent J. 2016;126(5):457-465. doi: 10.61872/sdj-2016-05-01.
8
The pH of beverages in the United States.美国饮料的pH值。
J Am Dent Assoc. 2016 Apr;147(4):255-63. doi: 10.1016/j.adaj.2015.10.019. Epub 2015 Dec 2.
9
Influence of various acidic beverages on tooth erosion. Evaluation by a new method.各种酸性饮料对牙齿侵蚀的影响。采用新方法进行评估。
PLoS One. 2015 Jun 2;10(6):e0129462. doi: 10.1371/journal.pone.0129462. eCollection 2015.
10
Dental erosion from an excess of vitamin C.因维生素C过量导致的牙齿侵蚀。
Case Rep Dent. 2014;2014:485387. doi: 10.1155/2014/485387. Epub 2014 Aug 4.