Gorman Megan, Ross Vanessa, Dos Santos Lisa, Al-Atassi Shaza, Frimer Marina
Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Long Island Jewish Medical Center, Northwell Health, New Hyde Park, NY, United States.
Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY, United States.
Gynecol Oncol Rep. 2025 Jan 17;57:101681. doi: 10.1016/j.gore.2025.101681. eCollection 2025 Feb.
Metastatic adenocarcinoma to the vulva is a rare phenomenon, with few cases reported in the literature. Here we discuss a 64-year-old woman with a history of colorectal adenocarcinoma presenting with a vulvar metastasis.
Clinical information was gathered via review of the electronic medical record.
IHC is useful in diagnosis of unusual metastases. In this case, staining for CDx2, CK20, PAX8, and CK7 was helpful in distinguishing a gynecologic versus gastrointestinal primary.
Our case highlights the importance of an accurate and timely diagnosis of gynecologic metastases in patients with a history of colorectal cancer. Examiners should have a low threshold for biopsy and imaging when patients present with skin changes or vulvovaginal complaints. Appropriate treatment requires a multidisciplinary approach.
外阴转移性腺癌是一种罕见现象,文献报道的病例很少。在此,我们讨论一名64岁有结肠直肠腺癌病史的女性,其出现了外阴转移。
通过查阅电子病历收集临床信息。
免疫组化有助于诊断不常见的转移瘤。在本病例中,细胞角蛋白20(CK20)、尾型同源盒转录因子2(CDx2)、配对盒基因8(PAX8)和细胞角蛋白7(CK7)染色有助于区分妇科原发性肿瘤与胃肠道原发性肿瘤。
我们的病例强调了对有结肠直肠癌病史的患者准确及时诊断妇科转移瘤的重要性。当患者出现皮肤改变或外阴阴道不适时,检查者应降低活检和影像学检查的阈值。适当的治疗需要多学科方法。