Pabuccu Emre, Tolunay Harun Egemen, Kocbulut Evren, Taskın Salih, Ortac Fırat, Sertcelik Ayse, Sasmaz Aysegul, Savas Berna
Ankara University School of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey.
Int J Clin Exp Pathol. 2012;5(6):609-13. Epub 2012 Jul 29.
To demonstrate a unique case report about late and isolated vulvar metastasis of sigmoid adeno-carcinoma with review of the literature.
MATERIAL-METHOD: 57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metastasis from a vulvar primary malignancy. Further imaging techniques were also performed to exclude additional tumours.
Immunohistochemistry (IHC) and KRAS gene mutation analysis revealed isolated metastasis of the colonic adeno-carcinoma in the vulva.
Isolated and late occurring vulvar metastasis of colonic origin is very unusual. Careful evaluation and IHC is useful for such cases.
通过文献回顾展示一例关于乙状结肠腺癌晚期孤立性外阴转移的独特病例报告。
一名57岁绝经后女性患者,既往有乙状结肠癌病史,因孤立性外阴肿物入院。术后进行免疫组织化学(IHC)和KRAS基因突变分析,以鉴别该转移灶与原发性外阴恶性肿瘤。还进行了进一步的影像学检查以排除其他肿瘤。
免疫组织化学(IHC)和KRAS基因突变分析显示结肠腺癌在外阴发生孤立性转移。
结肠源性孤立性晚期外阴转移非常罕见。对此类病例进行仔细评估和免疫组织化学检查很有用。