Alemany Laia, Felsher Marisa, Giuliano Anna R, Waterboer Tim, Mirghani Haitham, Mehanna Hisham, Roberts Craig, Chen Ya-Ting, Lara Núria, Lynam Mark, Torres Mayara, Pedrós Montse, Sanchez Emilio, Spitzer Jacque, Sirak Bradley, Quirós Beatriz, Carretero Gema, Paytubi Sonia, Morais Edith, Pavón Miquel Angel
Catalan Institute of Oncology. ICO, L'Hospitalet, Barcelona, Spain.
Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain.
EClinicalMedicine. 2025 Jan 15;79:103018. doi: 10.1016/j.eclinm.2024.103018. eCollection 2025 Jan.
HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence, yet there are few well-designed oral HPV epidemiology studies in general populations. This study assessed oral HPV prevalence and risk-factors among a general population in Europe and the United States (US).
The cross-sectional study was conducted between November 2020 and July 2023 in 105 dental offices in France, Germany, Spain, the United Kingdom (UK) and US. Participants were aged 18-60 and visiting dental clinics for routine examination. Participants provided oral gargle specimen for HPV DNA and genotyping and completed behavioral questionnaires. HPV DNA detection and genotyping was performed using SPF10/DEIA/LiPA25 at central laboratories.
Of 7674 participants, mean (SD) age was 40.0 (11.9), and 45.8% were males. Among men, any oral HPV prevalence ranged between countries from 6.6% to 15.0% and 1.8%-4.5% for high-risk (HR) types. Among women, any oral HPV prevalence ranged between countries from 3.6% to 6.8% and 0.2%-2.1% for HR types. HR infection among men was associated with older age (AOR 1.04; 95% CI: 1.02, 1.06); marijuana use (AOR 1.92; 95% CI: 1.19-3.11); increasing number of lifetime female oral sex partners; and by country, residing in the UK compared to Spain (AOR 2.89; 95% CI: 1.30-6.43). HR infection among women was associated with lifetime marijuana use (AOR 2.33; 95% CI: 1.18-4.60) and by country, residing in France compared to Spain (AOR 4.46; 95% CI: 1.26-15.77).
Oral HPV burden was highest among older men who may be at risk of developing OPSCC.
Funding for this research was provided by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.
人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌（OPSCC）发病率正在上升，但针对普通人群的精心设计的口腔HPV流行病学研究却很少。本研究评估了欧洲和美国普通人群中的口腔HPV流行率及风险因素。
这项横断面研究于2020年11月至2023年7月在法国、德国、西班牙、英国和美国的105家牙科诊所进行。参与者年龄在18至60岁之间，前往牙科诊所进行常规检查。参与者提供口腔含漱液样本用于HPV DNA检测和基因分型，并完成行为问卷。HPV DNA检测和基因分型在中央实验室使用SPF10/DEIA/LiPA25进行。
7674名参与者的平均（标准差）年龄为40.0（11.9）岁，45.8%为男性。在男性中，各国任何口腔HPV的流行率在6.6%至15.0%之间，高危（HR）型在1.8%至4.5%之间。在女性中，各国任何口腔HPV的流行率在3.6%至6.8%之间，HR型在0.2%至2.1%之间。男性中的HR感染与年龄较大（调整后比值比[AOR]1.04；95%置信区间[CI]：1.02，1.06）、使用大麻（AOR 1.92；95%CI：1.19 - 3.11）、一生中有女性口交性伴侣数量增加有关；按国家划分，与西班牙相比，居住在英国（AOR 2.89；95%CI：1.30 - 6.43）。女性中的HR感染与一生使用大麻（AOR 2.33；95%CI：1.18 - 4.60）以及按国家划分，与西班牙相比居住在法国（AOR 4.46；95%CI：1.26 - 15.77）有关。
口腔HPV负担在可能有患OPSCC风险的老年男性中最高。
本研究的资金由美国新泽西州拉威市默克公司的子公司默克夏普&多美公司有限责任公司提供。
