Porcaro Giuseppina, Calcagno Marco, Tinelli Andrea
Department of Gynecology and Obstetrics, Women's Health Centre, 05100 Terni, Italy.
Department of Woman Health and Reproductive Medicine, Santo Spirito Hospital, 00193 Rome, Italy.
Viruses. 2025 Jul 2;17(7):942. doi: 10.3390/v17070942.
Despite the fact that human papillomavirus (HPV) infections are common, there are currently no proven treatment approaches for persistent infections. A promising strategy to promote HPV clearance and the regression of caused lesions is dietary supplementation with natural compounds. This review evaluates available supplement formulations proposed in HPV care, focusing on combinations of epigallocatechin gallate (EGCG), folic acid (FA), vitamin B12 (B12), and hyaluronic acid (HA), as well as medicinal mushrooms and probiotics. The combination of EGCG, FA, B12, and HA is supported by the most consistent evidence, which shows a high rate of HPV clearance and lesion resolution across several clinical investigations. Medicinal mushrooms and probiotics have also shown some evidence of beneficial effects, although the diverse designs of the reported clinical studies may limit the observed findings. Overall, natural molecule-based supplements showed promising safety and efficacy profiles in the management of HPV persistent infection, supporting their clinical use. Of course, further investigations through well-designed, large-scale, randomized controlled trials will be necessary to provide strong support.
尽管人乳头瘤病毒（HPV）感染很常见，但目前尚无经证实的针对持续性感染的治疗方法。通过天然化合物进行膳食补充是促进HPV清除及所引起病变消退的一种有前景的策略。本综述评估了HPV防治中提出的现有补充剂配方，重点关注表没食子儿茶素没食子酸酯（EGCG）、叶酸（FA）、维生素B12（B12）和透明质酸（HA）的组合，以及药用蘑菇和益生菌。EGCG、FA、B12和HA的组合得到了最一致的证据支持，多项临床研究表明其HPV清除率和病变消退率很高。药用蘑菇和益生菌也显示出一些有益效果的证据，尽管所报道临床研究的多样设计可能会限制观察结果。总体而言，基于天然分子的补充剂在HPV持续性感染管理中显示出有前景的安全性和有效性，支持其临床应用。当然，需要通过设计良好的大规模随机对照试验进行进一步研究以提供有力支持。
