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健康受试者短期摄入δ-生育三烯酚对血脂谱的影响。

Short-term intake of delta-tocotrienol on lipid profiles in healthy subjects.

作者信息

Serizawa Naho, Ninomiya Yusuke, Shinagawa Akiho, Minematsu Ayako, Miyakoshi Yuichi, Yano Tomohiro, Ota Masako

机构信息

Department of Nutritional Sciences, Faculty of Health and Sports Sciences, Toyo University, Kita-ku, Tokyo 115-8650, Japan.

Institute of Life Innovation Studies, Toyo University, Kita-ku, Tokyo 115-8650, Japan.

出版信息

J Clin Biochem Nutr. 2025 Jan;76(1):3-7. doi: 10.3164/jcbn.24-124. Epub 2024 Oct 11.

DOI:10.3164/jcbn.24-124
PMID:39896164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11782774/
Abstract

Delta-tocotrienol (δ-T3) are beneficial for lipid metabolism. However, there are almost no reports on the specific numerical values of changes in blood tocotrienol levels when Japanese people consume tocotrienol. To observe the effect on blood δ-T3 and lipid concentrations after taking δ-T3, a crossover test was conducted with a control group, alpha-tocopherol (α-TP) group (264 ‍mg/day), and δ-T3 group (250 ‍mg/day). Participants took the target supplements for 14 days. This study revealed that plasma δ-T3 concentrations in healthy men and women increased significantly even with short-term intake (pre; 0.11 ± 0.03 to post; 0.40 ± 0.19 ‍μmol/L). The results of this study showed that α-TP and δ-T3 intake did not significantly affect any of the lipid profiles. However, the intake of δ-T3 tended to increase Low-density lipoprotein cholesterol (HDL-C) levels (pre: 59 ± 17 to post: 64 ± 20 ‍mg/dl). These results provide new evidence on changes in blood δ-T3 concentrations with δ-T3 intake in young people and suggest the potential of δ-T3 for the prevention of atherosclerosis.

摘要

δ-生育三烯酚（δ-T3）对脂质代谢有益。然而，关于日本人摄入生育三烯酚后血液中生育三烯酚水平变化的具体数值几乎没有相关报道。为了观察服用δ-T3后对血液中δ-T3和脂质浓度的影响，对对照组、α-生育酚（α-TP）组（264毫克/天）和δ-T3组（250毫克/天）进行了交叉试验。参与者服用目标补充剂14天。这项研究表明，即使短期摄入，健康男性和女性的血浆δ-T3浓度也显著增加（摄入前；0.11±0.03至摄入后；0.40±0.19微摩尔/升）。这项研究结果表明，摄入α-TP和δ-T3对任何脂质谱均无显著影响。然而，摄入δ-T3有使高密度脂蛋白胆固醇（HDL-C）水平升高的趋势（摄入前：59±17至摄入后：64±20毫克/分升）。这些结果为年轻人摄入δ-T3后血液δ-T3浓度的变化提供了新的证据，并提示δ-T3在预防动脉粥样硬化方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91db/11782774/f663070985c2/jcbn24-124f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91db/11782774/dcd7468bf708/jcbn24-124f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91db/11782774/f663070985c2/jcbn24-124f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91db/11782774/dcd7468bf708/jcbn24-124f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91db/11782774/f663070985c2/jcbn24-124f02.jpg

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本文引用的文献

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J Clin Biochem Nutr. 2022 Mar;70(2):140-146. doi: 10.3164/jcbn.21-69. Epub 2021 Oct 2.
2
Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.生育三烯酚补充对炎症和氧化应激标志物的影响：随机对照试验的系统评价和荟萃分析。
PLoS One. 2021 Jul 23;16(7):e0255205. doi: 10.1371/journal.pone.0255205. eCollection 2021.
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The effects of tocotrienol supplementation on lipid profile: A meta-analysis of randomized controlled trials.
生育三烯酚补充剂对血脂谱的影响：一项随机对照试验的荟萃分析。
Complement Ther Med. 2020 Aug;52:102450. doi: 10.1016/j.ctim.2020.102450. Epub 2020 May 25.
4
A 12-week evaluation of annatto tocotrienol supplementation for postmenopausal women: safety, quality of life, body composition, physical activity, and nutrient intake.一项为期 12 周的安那托生育三烯酚补充剂对绝经后妇女的评估：安全性、生活质量、身体成分、身体活动和营养摄入。
BMC Complement Altern Med. 2018 Jun 28;18(1):198. doi: 10.1186/s12906-018-2263-0.
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Both comprehensive and brief self-administered diet history questionnaires satisfactorily rank nutrient intakes in Japanese adults.综合性和简洁的自我管理饮食史问卷都能令人满意地对日本成年人的营养素摄入量进行排序。
J Epidemiol. 2012;22(2):151-9. doi: 10.2188/jea.je20110075. Epub 2012 Feb 18.
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