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特泽佩umab治疗后运动诱发的重度哮喘中的三维支气管树可视化

Three-dimensional bronchial tree visualization in exercise-induced severe asthma following tezepelumab treatment.

作者信息

Kai Yoshiro, Hishida Yuichi

机构信息

Department of Respiratory Medicine, Minami-Nara General Medical Center, Nara, Japan.

Department of Respiratory Medicine, Nara Medical University, Nara, Japan.

出版信息

J Allergy Clin Immunol Glob. 2024 Dec 24;4(2):100398. doi: 10.1016/j.jacig.2024.100398. eCollection 2025 May.

DOI:10.1016/j.jacig.2024.100398
PMID:39896213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11783099/
Abstract

Airway hyperresponsiveness, a key feature of asthma, is associated with exercise-induced asthma. Tezepelumab was reported to reduce airway hyperresponsiveness. Tezepelumab was confirmed through 3-dimensional bronchial tree visualization to be effective for exercise-induced asthma, reducing the need for a short-acting β2 agonist.

摘要

气道高反应性是哮喘的一个关键特征，与运动诱发性哮喘相关。据报道，tezepelumab可降低气道高反应性。通过三维支气管树可视化证实，tezepelumab对运动诱发性哮喘有效，减少了对短效β2激动剂的需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b28b/11783099/a0130cd1768e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b28b/11783099/a0130cd1768e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b28b/11783099/a0130cd1768e/gr1.jpg

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本文引用的文献

1
Airway hyperresponsiveness in asthma: The role of the epithelium.哮喘中的气道高反应性：上皮细胞的作用。
J Allergy Clin Immunol. 2024 May;153(5):1181-1193. doi: 10.1016/j.jaci.2024.02.011. Epub 2024 Feb 21.
2
Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma.特泽布尔单抗联合黏液栓在中重度哮喘患者中的应用
NEJM Evid. 2023 Oct;2(10):EVIDoa2300135. doi: 10.1056/EVIDoa2300135. Epub 2023 Sep 20.
3
Effect of Biologic Therapies on Airway Hyperresponsiveness and Allergic Response: A Systematic Literature Review.
生物疗法对气道高反应性和过敏反应的影响：一项系统文献综述
J Asthma Allergy. 2023 Jul 21;16:755-774. doi: 10.2147/JAA.S410592. eCollection 2023.
4
Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial.特泽普单抗对中重度未控制哮喘（CASCADE）患者气道炎症细胞、重塑和高反应性的影响：一项双盲、随机、安慰剂对照、2 期临床试验。
Lancet Respir Med. 2021 Nov;9(11):1299-1312. doi: 10.1016/S2213-2600(21)00226-5. Epub 2021 Jul 10.
5
Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.特泽布尔单抗在成人和青少年重症、未控制哮喘中的应用。
N Engl J Med. 2021 May 13;384(19):1800-1809. doi: 10.1056/NEJMoa2034975.
6
CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma.CT 和功能性磁共振成像评估严重哮喘的气道黏液。
Chest. 2019 Jun;155(6):1178-1189. doi: 10.1016/j.chest.2019.02.403. Epub 2019 Mar 23.
7
Autopsy and Imaging Studies of Mucus in Asthma. Lessons Learned about Disease Mechanisms and the Role of Mucus in Airflow Obstruction.哮喘黏液的尸检和影像学研究。关于疾病机制和黏液在气流阻塞中的作用的经验教训。
Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S184-S191. doi: 10.1513/AnnalsATS.201807-485AW.
8
ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing.ERS 技术标准：支气管激发试验——间接气道激发试验的病理生理学和方法学。
Eur Respir J. 2018 Nov 15;52(5). doi: 10.1183/13993003.01033-2018. Print 2018 Nov.
9
A surrogate marker of airway hyperresponsiveness in patients with bronchial asthma.支气管哮喘患者气道高反应性的替代标志物。
Allergol Int. 2014 Sep;63(3):487-8. doi: 10.2332/allergolint.13-LE-0656. Epub 2014 May 25.
10
Bronchial and alveolar nitric oxide in exercise-induced bronchoconstriction in asthmatic children.支气管和肺泡一氧化氮在哮喘儿童运动性支气管收缩中的作用。
Clin Exp Allergy. 2012 Aug;42(8):1190-6. doi: 10.1111/j.1365-2222.2012.03973.x.