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Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system.

作者信息

Luo Qian, Yang Jiaying, Yang Mei, Wang Yingtong, Liu Yiran, Liu Jixuan, Kalvakolanu Dhan V, Cong Xianling, Zhang Jinnan, Zhang Ling, Guo Baofeng, Duo Yanhong

机构信息

Department of Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China.

Key Laboratory of Pathobiology, Ministry of Education, And Department of Biomedical Science, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.

出版信息

Mater Today Bio. 2025 Jan 4;31:101457. doi: 10.1016/j.mtbio.2025.101457. eCollection 2025 Apr.

DOI:10.1016/j.mtbio.2025.101457
PMID:39896289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11786670/
Abstract

Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the blood-brain barrier (BBB), drug delivery for CNS diseases is extremely challenging. Nano-delivery systems can overcome the limitations of BBB to deliver drugs to the CNS, improve the ability of drugs to target the brain and provide potential therapeutic methods for CNS diseases. At the same time, the choice of different drug delivery methods (bypassing BBB or crossing BBB) can further optimize the therapeutic effect of the nano-drug delivery system. This article reviews the different methods of nano-delivery systems to overcome the way BBB enters the brain. Different kinds of nanoparticles to overcome BBB were discussed in depth.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/2f11333dea06/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/ee3a73883a63/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/8e5f2b25f22f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/563fc1e53402/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/c1c24797ac6a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/87971eb179a8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/1779cc272159/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/0e2b5e956ad0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/f337266aef21/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/3ee85a9c1d15/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/2f11333dea06/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/ee3a73883a63/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/8e5f2b25f22f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/563fc1e53402/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/c1c24797ac6a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/87971eb179a8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/1779cc272159/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/0e2b5e956ad0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/f337266aef21/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/3ee85a9c1d15/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea32/11786670/2f11333dea06/gr9.jpg

相似文献

[1]
Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system.

Mater Today Bio. 2025-1-4

[2]
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[3]
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[4]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
The Association Between Indoor Air Pollutants and Brain Structure Indicators Using eTIV-Adjusted and Unadjusted Models: A Study in Seoul and Incheon.

Brain Sci. 2025-8-14

[2]
Overcoming the blood-brain barrier (BBB) in pediatric CNS tumors: immunotherapy and nanomedicine-driven strategies.

Med Oncol. 2025-8-19

[3]
Immunological Insights into Photodynamic Therapy of Glioblastoma Multiforme.

Molecules. 2025-7-24

本文引用的文献

[1]
Application and advances of biomimetic membrane materials in central nervous system disorders.

J Nanobiotechnology. 2024-5-23

[2]
Effective glioblastoma immune sonodynamic treatment mediated by macrophage cell membrane cloaked biomimetic nanomedicines.

J Control Release. 2024-6

[3]
Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases.

Adv Drug Deliv Rev. 2024-6

[4]
Ultrasmall iron oxide nanoparticles with MRgFUS for enhanced magnetic resonance imaging of orthotopic glioblastoma.

J Mater Chem B. 2024-5-22

[5]
Efficient Delivery of Lomitapide using Hybrid Membrane-Coated Tetrahedral DNA Nanostructures for Glioblastoma Therapy.

Adv Mater. 2024-6

[6]
Blood-Brain Barrier-Penetrating and Lesion-Targeting Nanoplatforms Inspired by the Pathophysiological Features for Synergistic Ischemic Stroke Therapy.

Adv Mater. 2024-5

[7]
Functionalized Nanomaterials Capable of Crossing the Blood-Brain Barrier.

ACS Nano. 2024-1-23

[8]
Drug Delivery to the Brain: Recent Advances and Unmet Challenges.

Pharmaceutics. 2023-11-23

[9]
Erythrocyte membrane-coated nanocarriers modified by TGN for Alzheimer's disease.

J Control Release. 2024-2

[10]
Biomimetic Macrophage Membrane-Camouflaged Nanoparticles Induce Ferroptosis by Promoting Mitochondrial Damage in Glioblastoma.

ACS Nano. 2023-12-12

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