Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, 226001, China.
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, China.
J Nanobiotechnology. 2024 May 23;22(1):280. doi: 10.1186/s12951-024-02548-8.
Central nervous system (CNS) diseases encompass spinal cord injuries, brain tumors, neurodegenerative diseases, and ischemic strokes. Recently, there has been a growing global recognition of CNS disorders as a leading cause of disability and death in humans and the second most common cause of death worldwide. The global burdens and treatment challenges posed by CNS disorders are particularly significant in the context of a rapidly expanding global population and aging demographics. The blood-brain barrier (BBB) presents a challenge for effective drug delivery in CNS disorders, as conventional drugs often have limited penetration into the brain. Advances in biomimetic membrane nanomaterials technology have shown promise in enhancing drug delivery for various CNS disorders, leveraging properties such as natural biological surfaces, high biocompatibility and biosafety. This review discusses recent developments in biomimetic membrane materials, summarizes the types and preparation methods of these materials, analyzes their applications in treating CNS injuries, and provides insights into the future prospects and limitations of biomimetic membrane materials.
中枢神经系统（CNS）疾病包括脊髓损伤、脑肿瘤、神经退行性疾病和缺血性中风。最近，人们越来越认识到 CNS 疾病是导致人类残疾和死亡的主要原因，也是全球第二大致死原因。在全球人口迅速增长和人口老龄化的背景下，CNS 疾病带来的全球负担和治疗挑战尤为显著。血脑屏障（BBB）对 CNS 疾病的有效药物输送构成挑战，因为常规药物往往难以穿透大脑。仿生膜纳米材料技术的进步在增强各种 CNS 疾病的药物输送方面显示出了前景，利用了天然生物表面、高生物相容性和生物安全性等特性。本文讨论了仿生膜材料的最新进展，总结了这些材料的类型和制备方法，分析了它们在 CNS 损伤治疗中的应用，并对仿生膜材料的未来前景和局限性提出了见解。
