Shi Huayun, Mohan Muktesh, Singh Kanwarpal, Sadler Peter J
Department of Chemistry, University of Warwick Coventry CV4 7AL UK
State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University Xiamen 361102 China.
RSC Adv. 2025 Jan 31;15(5):3168-3171. doi: 10.1039/d4ra08693g. eCollection 2025 Jan 29.
Photoactive diazido Pt(iv) complexes display anticancer efficacy towards oesophageal tumours, a worldwide common cancer. Here we explore the use of optical coherence tomography (OCT) as a new method for detecting tissue penetration and damage produced by the photoactivatable anticancer complex ,,-[Pt(pyridine)(N)(OH)] (FM190). Dehydration of the sample and a change in refractive index were observed for swine oesophageal tissue treated with FM190 and blue laser light (445 nm) using an OCT system. In contrast, tissues treated with FM190 or laser light alone showed no apparent damage.
光活性二叠氮铂（IV）配合物对食管癌具有抗癌疗效，食管癌是一种全球常见的癌症。在这里，我们探索使用光学相干断层扫描（OCT）作为一种新方法，来检测可光激活的抗癌配合物，即，，-[Pt（吡啶）（N）（OH）]（FM190）所产生的组织穿透和损伤情况。使用OCT系统观察到，用FM190和蓝光（445nm）处理过的猪食管组织出现了样品脱水和折射率变化。相比之下，单独用FM190或激光处理的组织没有明显损伤。
