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2型糖尿病患者停用胰高血糖素样肽-1受体激动剂治疗的自然疗法管理:一例报告

Naturopathic Management to Taper Off Glucagon-Like Peptide-1 Receptor Agonist Therapy in Type 2 Diabetes: A Case Report.

作者信息

Linder Leah

出版信息

Integr Med (Encinitas). 2025 Feb;24(1):26-30.

Abstract

This case report presents a 46-year-old woman with type 2 diabetes mellitus (T2DM) who sought to discontinue glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) therapy while maintaining her weight and metabolic health. Her desire to reduce medication dependency, combined with her apprehension about potential metabolic regression following discontinuation of the drug, highlights a challenge often faced by patients managing chronic conditions, and the value of naturopathic adjunctive therapies to support these individuals in their wellness goals. This report details a comprehensive intervention strategy combining probiotics, nutrient supplementation, and lifestyle modifications to address her concerns. Over an 8-week period post-GLP-1 RAs therapy discontinuation, she maintained weight loss, improved glycemic control and lipid profile, demonstrated improvements in micronutrient levels, and experienced improvements in her quality of life. This case contributes to the growing body of evidence suggesting that targeted naturopathic interventions can play a supportive role in managing T2DM and mitigating the reliance on pharmacotherapy without compromising health outcomes.

摘要

本病例报告介绍了一名46岁的2型糖尿病(T2DM)女性患者,她希望在维持体重和代谢健康的同时停用胰高血糖素样肽-1(GLP-1)受体激动剂(RA)治疗。她减少药物依赖的愿望,再加上对停药后可能出现代谢倒退的担忧,凸显了慢性病患者常面临的挑战,以及自然疗法辅助治疗对帮助这些个体实现健康目标的价值。本报告详细介绍了一种综合干预策略,该策略结合了益生菌、营养补充和生活方式改变,以解决她的担忧。在停用GLP-1 RA治疗后的8周内,她保持了体重减轻,改善了血糖控制和血脂水平,微量营养素水平有所提高,生活质量也得到改善。该病例为越来越多的证据提供了补充,表明有针对性的自然疗法干预在管理T2DM和减少对药物治疗的依赖方面可发挥支持作用,同时不影响健康结果。

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